公开(公告)号：EP0385468B1

公开(公告)日：1992-08-26

申请号：EP90104007.1

申请日：1990-03-01

申请人： MEIJI SEIKA KAISHA LTD. ,  ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI

发明人： Hosoi, Kaoru, c/o Pharmaceutical Research Center ,  Ishizawa, Takayuki, Pharmaceutical Research Center ,  Okada, Makoto, Pharmaceutical Research Center ,  Yoneta, Toshio, Pharmaceutical Research Center ,  Murata, Shinjiro, Pharmaceutical Research Center ,  Fukatsu, Shunzo, Pharmaceutical Research Center ,  Tsuchiya, Tsutomu

IPC分类号： A61K31/71 ,  A61K47/26 ,  A61K9/14

CPC分类号： A61K31/70 ,  A61K9/0019 ,  A61K9/19 ,  A61K47/26

公开(公告)号：EP0385468A1

公开(公告)日：1990-09-05

申请号：EP90104007.1

申请日：1990-03-01

申请人： MEIJI SEIKA KAISHA LTD. ,  ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI

发明人： Hosoi, Kaoru, c/o Pharmaceutical Research Center ,  Ishizawa, Takayuki, Pharmaceutical Research Center ,  Okada, Makoto, Pharmaceutical Research Center ,  Yoneta, Toshio, Pharmaceutical Research Center ,  Murata, Shinjiro, Pharmaceutical Research Center ,  Fukatsu, Shunzo, Pharmaceutical Research Center ,  Tsuchiya, Tsutomu

IPC分类号： A61K31/71 ,  A61K47/26 ,  A61K9/14

CPC分类号： A61K31/70 ,  A61K9/0019 ,  A61K9/19 ,  A61K47/26

摘要： According to this invention there is provided a new stabilized antitumor composition comprising a mixture of an antitumor anthracycline compound of formula (I)
or a non-toxic salt thereof with lactose, with the lactose being incorporated as a stabilizing agent in the mixture in an amount effective to stabilize the anthracycline compound of formula (I) or its salt from its degradation and thus with the weight ratio between the anthracycline compound or its salt and lactose being in a range of 1 : 0.5 to 1 : 8. There is also provided a method for stabilizing the anthracycline compound of formula (I) or its salt by mixing with lactose in the required proportions.

摘要翻译： 根据本发明，提供了一种新的稳定化的抗肿瘤组合物，其包含式（I）的抗肿瘤蒽环类化合物或其无毒盐与乳糖的混合物，乳糖作为稳定剂掺入混合物中 其量有效地使式（I）的蒽环类化合物或其盐从其降解稳定，因此蒽环化合物或其盐与乳糖的重量比在1:0.5至1:8的范围内。存在 还提供了通过以所需比例与乳糖混合来稳定式（I）的蒽环类化合物或其盐的方法。