发明公开
- 专利标题： Novel polypeptide and production thereof
- 专利标题（中）： Polypeptid和dessen Herstellung。
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申请号： EP90104419.8申请日： 1990-03-08
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公开(公告)号： EP0386752A1公开(公告)日： 1990-09-12
- 发明人: Nakahama, Kazuo , Kaisho, Yoshihiko , Yoshimura, Koji , Sasada, Reiko
- 申请人： Takeda Chemical Industries, Ltd.
- 申请人地址： 1-1, Doshomachi 4-chome Chuo-ku, Osaka JP
- 专利权人： Takeda Chemical Industries, Ltd.
- 当前专利权人： Takeda Chemical Industries, Ltd.
- 当前专利权人地址： 1-1, Doshomachi 4-chome Chuo-ku, Osaka JP
- 代理机构： von Kreisler, Alek, Dipl.-Chem.
- 优先权： JP58983/89 19890310; JP127710/89 19890519; JP193654/89 19890726; JP263613/89 19891009
- 主分类号： C12N15/18
- IPC分类号： C12N15/18 ; C07K7/10 ; C07H21/04 ; C12N1/21 ; C12N1/19 ; C12P21/00
摘要：
Disclosed are (1) a polypeptide (I) including the following amino acid sequence (II) in a molecule thereof:
TyrAlaGluHisLysSerHisArgGlyGluTyrSerValCys
AspSerGluSerLeuTrpValThrAspLysSerSerAlaIle
AspIleArgGlyHisGlnValThrValLeuGlyGluIleLys
ThrGlyAsnSerProValLysGlnTyrPheTyrGluThrArg
CysLysGluAlaArgProValLysAsnGlyCysArgGlyIle
AspAspLysHisTrpAsnSerGlnCysLysThrSerGlnThr
TyrValArgAlaLeuThrSerGluAsnAsnLysLeuValGly
TrpArgTrpIleArgIleAspThrSerCysValCysAlaLeu
SerArgLysIleGlyArg (II)
(2) a DNA sequence coding for the polypeptide described in (1), (3) a vector including the DNA described in (2), (4) a transformant transformed by the vector described in (3), and (5) a process for producing the polypeptide (I) which comprises cultivating the transformant described in (4) in a culture medium to produce and accumulate the polypeptide described in (1) in a culture. The polypeptide is useful as a reagent for studies relating to the differentiation, growth and survival of animal cells, and may also be useful as a drug.
TyrAlaGluHisLysSerHisArgGlyGluTyrSerValCys
AspSerGluSerLeuTrpValThrAspLysSerSerAlaIle
AspIleArgGlyHisGlnValThrValLeuGlyGluIleLys
ThrGlyAsnSerProValLysGlnTyrPheTyrGluThrArg
CysLysGluAlaArgProValLysAsnGlyCysArgGlyIle
AspAspLysHisTrpAsnSerGlnCysLysThrSerGlnThr
TyrValArgAlaLeuThrSerGluAsnAsnLysLeuValGly
TrpArgTrpIleArgIleAspThrSerCysValCysAlaLeu
SerArgLysIleGlyArg (II)
(2) a DNA sequence coding for the polypeptide described in (1), (3) a vector including the DNA described in (2), (4) a transformant transformed by the vector described in (3), and (5) a process for producing the polypeptide (I) which comprises cultivating the transformant described in (4) in a culture medium to produce and accumulate the polypeptide described in (1) in a culture. The polypeptide is useful as a reagent for studies relating to the differentiation, growth and survival of animal cells, and may also be useful as a drug.
公开/授权文献
- EP0386752B1 Novel polypeptide and production thereof 公开/授权日：1994-09-14
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