发明公开
- 专利标题： Steroid derivatives,processes for their preparation and pharmaceutical compositions thereof
- 专利标题（中）： 甾体衍生物，其制备方法及其药物组合物
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申请号： EP90302543.5申请日： 1990-03-09
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公开(公告)号： EP0387090A3公开(公告)日： 1992-05-06
- 发明人: Molnar, Csaba , Hajos, Gyorgy , Szporny, Laszlo , Toth, Jozsef , Kiraly, Arpad , Boor nee Mezei, Arma , Csorgei, Janos , Szekely, Krisztina , Forgacs, Lilla , Fekete, Gyorgy , Herenyi, of Bulcsu , Holly, Sandor , Szunyog, Jozef
- 申请人： RICHTER GEDEON VEGYESZETI GYAR R.T.
- 申请人地址： Gyömröi ut 19-21 H-1475 Budapest HU
- 专利权人： RICHTER GEDEON VEGYESZETI GYAR R.T.
- 当前专利权人： RICHTER GEDEON VEGYESZETI GYAR R.T.
- 当前专利权人地址： Gyömröi ut 19-21 H-1475 Budapest HU
- 代理机构： Pett, Christopher Phineas
- 优先权： HU115589 19890309
- 主分类号： C07J71/00
- IPC分类号： C07J71/00 ; C07J7/00 ; A61K31/58
摘要：
The invention relates to novel Δ¹⁴-16α,17-dihydroxy-pregnane-16,17-cyclic aldehyde acetal and -cyclic ketone ketal derivatives of general formula (I),
wherein
A stands for hydrogen or hydroxyl group;
X stands for hydrogen or halogen with the proviso that if A is hydrogen, then X also means hydrogen;
R stands for hydrogen,benzoyl or C₁ ⁻ ₈alkanoyl group;
R¹ and R², which are the same or different, stand for hydrogen or a C₁ ⁻ ₄alkyl group; or one of R¹ and R² is hydrogen and the other is phenyl group; or R¹ and R² together form a C₄ ⁻ ₅alkylene group; --- means a single or double bond between two adjacent carbon atoms,
as well as pharmaceutical compositions containing these compounds and a process for their preparation. The compounds of general formula (I) possess a very strong antiinflammatory effect and only week harmful side effect. Thus, they can be used as active ingredients of antiinflammatory pharmaceutical compositions being useful in the therapy.
wherein
A stands for hydrogen or hydroxyl group;
X stands for hydrogen or halogen with the proviso that if A is hydrogen, then X also means hydrogen;
R stands for hydrogen,benzoyl or C₁ ⁻ ₈alkanoyl group;
R¹ and R², which are the same or different, stand for hydrogen or a C₁ ⁻ ₄alkyl group; or one of R¹ and R² is hydrogen and the other is phenyl group; or R¹ and R² together form a C₄ ⁻ ₅alkylene group; --- means a single or double bond between two adjacent carbon atoms,
as well as pharmaceutical compositions containing these compounds and a process for their preparation. The compounds of general formula (I) possess a very strong antiinflammatory effect and only week harmful side effect. Thus, they can be used as active ingredients of antiinflammatory pharmaceutical compositions being useful in the therapy.
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