发明公开
EP0398578A2 2-piperidino-1-alkanol derivatives as antiischemic agents
失效
2-哌啶子基-1-链烷醇 - 衍生物抗血清Wirkstoffe。
- 专利标题： 2-piperidino-1-alkanol derivatives as antiischemic agents
- 专利标题（中）： 2-哌啶子基-1-链烷醇 - 衍生物抗血清Wirkstoffe。
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申请号： EP90304975.7申请日： 1990-05-09
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公开(公告)号： EP0398578A2公开(公告)日： 1990-11-22
- 发明人: Chenard, Bertrand Leo
- 申请人： PFIZER INC.
- 申请人地址： 235 East 42nd Street New York, N.Y. 10017 US
- 专利权人： PFIZER INC.
- 当前专利权人： PFIZER INC.
- 当前专利权人地址： 235 East 42nd Street New York, N.Y. 10017 US
- 代理机构： Moore, James William, Dr.
- 优先权： PCT/US89/02176 19890517; PCT/US90/00292 19900116
- 主分类号： C07D451/02
- IPC分类号： C07D451/02 ; A61K31/33 ; A61K31/695 ; C07D211/54 ; C07D211/48 ; C07D491/10 ; C07D451/06 ; C07D207/12 ; C07F7/18
摘要：
2-(8-Azabicyclo[3.2.1]oct-8-yl)alkanols of the formula
wherein Q is S or CH=CH; X is H, OH or another aromatic substituent; R is hydrogen, alkyl, alkenyl or alkynyl; Y and Y 1 are taken together and are arylmethylene or aralkylmethylene (or a corresponding epoxy derivative) or Y and Y 1 are taken separately and Y is hydrogen or OH, and Y 1 is aryl, aralkyl, arylthio, or aryloxy; and structurally related 2-(piperidino)alkanols; pharmaceutical compositions thereof; methods of treating CNS disorders therewith; and intermediates useful in the preparation of said compounds.
wherein Q is S or CH=CH; X is H, OH or another aromatic substituent; R is hydrogen, alkyl, alkenyl or alkynyl; Y and Y 1 are taken together and are arylmethylene or aralkylmethylene (or a corresponding epoxy derivative) or Y and Y 1 are taken separately and Y is hydrogen or OH, and Y 1 is aryl, aralkyl, arylthio, or aryloxy; and structurally related 2-(piperidino)alkanols; pharmaceutical compositions thereof; methods of treating CNS disorders therewith; and intermediates useful in the preparation of said compounds.
公开/授权文献
- EP0398578B1 2-piperidino-1-alkanol derivatives as antiischemic agents 公开/授权日：1997-03-12
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