发明公开
EP0402699A3 Chromogenic dibenzoxazepinone and dibenzothiazepinone enzyme substrates
失效
色素二苯并恶唑酮和二苯并噻吩酮酶基质
- 专利标题： Chromogenic dibenzoxazepinone and dibenzothiazepinone enzyme substrates
- 专利标题（中）： 色素二苯并恶唑酮和二苯并噻吩酮酶基质
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申请号： EP90110198.0申请日： 1990-05-30
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公开(公告)号： EP0402699A3公开(公告)日： 1991-01-30
- 发明人: Corey, Paul F.
- 申请人： MILES INC.
- 申请人地址： 1127 Myrtle Street Elkhart Indiana 46514 US
- 专利权人： MILES INC.
- 当前专利权人： MILES INC.
- 当前专利权人地址： 1127 Myrtle Street Elkhart Indiana 46514 US
- 代理机构： Kirchner, Dietrich, Dr.
- 优先权： US364157 19890612
- 主分类号： C07H15/26
- IPC分类号： C07H15/26 ; C07H17/00 ; C12Q1/34
摘要：
Chromogenic enzyme substrate compounds comprising a dibenz[b,e] [1,4]oxazepinone or dibenzo[b,e][1,4]thiazepinone nucleus having an enzyme-cleavable group such as a radical of a sugar, carboxylic acid, amino acid, peptide, phosphoric acid, or sulfuric acid. The substrate compounds are, in general, highly soluble in aqueous media and only slightly colored, and produce, upon enzyme cleavage, a chromogen exhibiting a large change in absorbance and a pKa below 7. Such substrates find use as indicators for the determination of enzyme analytes and enzymes used as markers in a variety of assays, including immunoassays.
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