发明公开
EP0408106A2 Novel acrylic amide derivatives, a process for their preparation, pharmaceutical compositions containing the same and their use in medicine
失效
丙烯酰胺衍生物，它们的制备方法，含有它们和它们在医学中使用的药物组合物。
- 专利标题： Novel acrylic amide derivatives, a process for their preparation, pharmaceutical compositions containing the same and their use in medicine
- 专利标题（中）： 丙烯酰胺衍生物，它们的制备方法，含有它们和它们在医学中使用的药物组合物。
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申请号： EP90201742.5申请日： 1990-06-29
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公开(公告)号： EP0408106A2公开(公告)日： 1991-01-16
- 发明人: Fodor, Tamas , Fischer, Janos , Dobay, Laszlo , Ezer, Elemér , Matuz, Judit , Saghy, Katalin , Szporny, Laszlo , Hajos, György
- 申请人： RICHTER GEDEON VEGYESZETI GYAR R.T.
- 申请人地址： Gyömröi ut 19-21 H-1103 Budapest X HU
- 专利权人： RICHTER GEDEON VEGYESZETI GYAR R.T.
- 当前专利权人： RICHTER GEDEON VEGYESZETI GYAR R.T.
- 当前专利权人地址： Gyömröi ut 19-21 H-1103 Budapest X HU
- 代理机构： Kupecz, Arpad
- 优先权： HU357189 19890714
- 主分类号： C07C323/60
- IPC分类号： C07C323/60 ; C07C317/24 ; A61K31/10 ; C07C315/04 ; C07C319/20 ; C07D295/18 ; C07D277/06
摘要：
Novel acrylic amide derivative of the formula
wherein
R¹ represents a hydrogen or a halogen atom or a C₁₋₄alkyl, a C₁₋₄alkoxy or a nitro group.
n is an integer of 0 to 2,
A represents an amino acid residue derived from a naturally occuring amino acid or an antipode thereof which is connected to the acrylic acyl residue through its amino group; or a residue derived from thiazolidinecarboxylic acid connected to the acrylic acyl group through its nitrogen, or a derivative of the above residues wherein any free carboxy group is esterified with a C₁₋₄alkyl group or is amidated; or A represents a group of formula
wherein
R₂ is a hydrogen atom or a phenyl, a C₁₋₄alkyl or a C₁₋₄alkoxycarbonyl group,
and their salts which have interesting cytoprotective and antiulcer activities are provided. A process is also described for the preparation of said compounds.
wherein
R¹ represents a hydrogen or a halogen atom or a C₁₋₄alkyl, a C₁₋₄alkoxy or a nitro group.
n is an integer of 0 to 2,
A represents an amino acid residue derived from a naturally occuring amino acid or an antipode thereof which is connected to the acrylic acyl residue through its amino group; or a residue derived from thiazolidinecarboxylic acid connected to the acrylic acyl group through its nitrogen, or a derivative of the above residues wherein any free carboxy group is esterified with a C₁₋₄alkyl group or is amidated; or A represents a group of formula
wherein
R₂ is a hydrogen atom or a phenyl, a C₁₋₄alkyl or a C₁₋₄alkoxycarbonyl group,
and their salts which have interesting cytoprotective and antiulcer activities are provided. A process is also described for the preparation of said compounds.
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