发明公开
- 专利标题: Piperidylthiocarbapenem derivatives
- 专利标题(中): 哌嗪代谢衍生物
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申请号: EP90114868.4申请日: 1990-08-02
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公开(公告)号: EP0411636A3公开(公告)日: 1991-07-17
- 发明人: Nakagawa, Susumu, C/o Banyu Pharmaceutical Co.,Ltd , Kato, Shinji, C/o Banyu Pharmaceutical Co.,Ltd , Fukatsu, Hiroshi, C/o Banyu Pharmaceutical Co.,Ltd
- 申请人: BANYU PHARMACEUTICAL CO., LTD.
- 申请人地址: 2-3, Nihonbashi Honcho 2-chome Chuo-ku, Tokyo JP
- 专利权人: BANYU PHARMACEUTICAL CO., LTD.
- 当前专利权人: BANYU PHARMACEUTICAL CO., LTD.
- 当前专利权人地址: 2-3, Nihonbashi Honcho 2-chome Chuo-ku, Tokyo JP
- 代理机构: Hansen, Bernd, Dr. Dipl.-Chem.
- 优先权: JP200805/89 19890802
- 主分类号: C07D477/00
- IPC分类号: C07D477/00 ; C07D211/54 ; C07D211/60 ; A61K31/40
摘要:
A compound represented by the general formula (I):
wherein R¹ is a hydrogen atom or a methyl group; R² and R³, which may be the same or different, each represents a hydrogen atom or a lower alkyl group, or taken together with the adjacent nitrogen atom, jointly represent a heterocyclic group selected from the group consisting of an aziridinyl group, an azetidinyl group, a pyrrolidinyl group, a piperidino group, a piperazinyl group, a 4-lower alkylpiperazinyl group, a morpholino group and a thiomorpholino group; and A is a single bond, a lower alkylene group, a lower alkenylene group or a lower alkynylene group; or a pharmaceutically acceptable salt or ester thereof. The compound of the general formula (I) and their salts or esters exhibit excellent antibacterial activity.
wherein R¹ is a hydrogen atom or a methyl group; R² and R³, which may be the same or different, each represents a hydrogen atom or a lower alkyl group, or taken together with the adjacent nitrogen atom, jointly represent a heterocyclic group selected from the group consisting of an aziridinyl group, an azetidinyl group, a pyrrolidinyl group, a piperidino group, a piperazinyl group, a 4-lower alkylpiperazinyl group, a morpholino group and a thiomorpholino group; and A is a single bond, a lower alkylene group, a lower alkenylene group or a lower alkynylene group; or a pharmaceutically acceptable salt or ester thereof. The compound of the general formula (I) and their salts or esters exhibit excellent antibacterial activity.
公开/授权文献
- EP0411636B1 Piperidylthiocarbapenem derivatives 公开/授权日:1995-01-04
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