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    Piperidylthiocarbapenem derivatives
    3.
    发明公开
    Piperidylthiocarbapenem derivatives 失效
    哌啶硫基碳代青霉烯衍生物

    公开(公告)号：EP0411636A2

    公开(公告)日：1991-02-06

    申请号：EP90114868.4

    申请日：1990-08-02

    申请人： BANYU PHARMACEUTICAL CO., LTD.

    发明人： Nakagawa, Susumu, C/o Banyu Pharmaceutical Co.,Ltd ,  Kato, Shinji, C/o Banyu Pharmaceutical Co.,Ltd ,  Fukatsu, Hiroshi, C/o Banyu Pharmaceutical Co.,Ltd

    IPC分类号： C07D477/00 ,  C07D211/54 ,  C07D211/60 ,  A61K31/40

    CPC分类号： C07D477/20 ,  C07D211/54 ,  C07D211/60 ,  Y02P20/55

    摘要： A compound represented by the general formula (I):
    wherein R¹ is a hydrogen atom or a methyl group; R² and R³, which may be the same or different, each represents a hydrogen atom or a lower alkyl group, or taken together with the adjacent nitrogen atom, jointly represent a heterocyclic group selected from the group consisting of an aziridinyl group, an azetidinyl group, a pyrrolidinyl group, a piperidino group, a piperazinyl group, a 4-lower alkylpiperazinyl group, a morpholino group and a thiomorpholino group; and A is a single bond, a lower alkylene group, a lower alkenylene group or a lower alkynylene group; or a pharmaceutically acceptable salt or ester thereof.
    The compound of the general formula (I) and their salts or esters exhibit excellent antibacterial activity.

    摘要翻译： 由通式（I）表示的化合物：其中R 1是氢原子或甲基; R 2和R 3可以相同或不同，分别代表氢原子或低级烷基或与相邻的氮原子一起共同代表选自氮丙啶基，氮杂环丁烷基 吡咯烷基，哌啶子基，哌嗪基，4-低级烷基哌嗪基，吗啉基和硫代吗啉基; A是单键，低级亚烷基，低级亚烯基或低级亚炔基; 或其药学上可接受的盐或酯。 通式（I）的化合物及其盐或酯表现出优异的抗菌活性。