发明公开
- 专利标题： Nitrofurantoin crystals
- 专利标题（中）： Nitrofurantoinkristalle。
-
申请号： EP90201965.2申请日： 1990-07-18
-
公开(公告)号： EP0412592A1公开(公告)日： 1991-02-13
- 发明人: Cazer, Frederick Dana , Scott, Barry Lee , Kane, Michael John , Shahi, Vijay
- 申请人： Norwich Eaton Pharmaceuticals, Inc.
- 申请人地址： 17 Eaton Avenue Norwich New York 13815 US
- 专利权人： Norwich Eaton Pharmaceuticals, Inc.
- 当前专利权人： Norwich Eaton Pharmaceuticals, Inc.
- 当前专利权人地址： 17 Eaton Avenue Norwich New York 13815 US
- 代理机构： Brooks, Maxim Courtney
- 优先权： US386050 19890726
- 主分类号： C07D405/06
- IPC分类号： C07D405/06
摘要：
Nitrofurantoin particulates comprising discrete particulates of nitrofurantoin wherein:
(a) said particulates are larger than about 200 mesh size; and
(b) the BET surface area of said particulates is at least about 0.2 M²/g.
Preferably, the surface of said particulates consists essentially of nitrofurantoin monohydrate. Also preferably, said particulates comprise at least about 5%, more preferably at least about 50% of nitrofurantoin monohydrate. Preferred compositions of this invention comprise these nitrofurantoin particulates in an aqueous suspension. The nitrofurantoin particulates of this invention are highly efficacious for the delivery of nitrofurantoin in oral dosage forms.
(a) said particulates are larger than about 200 mesh size; and
(b) the BET surface area of said particulates is at least about 0.2 M²/g.
Preferably, the surface of said particulates consists essentially of nitrofurantoin monohydrate. Also preferably, said particulates comprise at least about 5%, more preferably at least about 50% of nitrofurantoin monohydrate. Preferred compositions of this invention comprise these nitrofurantoin particulates in an aqueous suspension. The nitrofurantoin particulates of this invention are highly efficacious for the delivery of nitrofurantoin in oral dosage forms.
公开/授权文献
- EP0412592B1 Nitrofurantoin crystals 公开/授权日：1995-06-21
信息查询
