公开(公告)号：EP0412592B1

公开(公告)日：1995-06-21

申请号：EP90201965.2

申请日：1990-07-18

申请人： Norwich Eaton Pharmaceuticals, Inc.

发明人： Cazer, Frederick Dana ,  Scott, Barry Lee ,  Kane, Michael John ,  Shahi, Vijay

IPC分类号： C07D405/06

CPC分类号： C07D405/12

公开(公告)号：EP0412592A1

公开(公告)日：1991-02-13

申请号：EP90201965.2

申请日：1990-07-18

申请人： Norwich Eaton Pharmaceuticals, Inc.

发明人： Cazer, Frederick Dana ,  Scott, Barry Lee ,  Kane, Michael John ,  Shahi, Vijay

IPC分类号： C07D405/06

CPC分类号： C07D405/12

摘要： Nitrofurantoin particulates comprising discrete particulates of nitrofurantoin wherein:

(a) said particulates are larger than about 200 mesh size; and
(b) the BET surface area of said particulates is at least about 0.2 M²/g.
Preferably, the surface of said particulates consists essentially of nitrofurantoin monohydrate. Also preferably, said particulates comprise at least about 5%, more preferably at least about 50% of nitrofurantoin monohydrate. Preferred compositions of this invention comprise these nitrofurantoin particulates in an aqueous suspension. The nitrofurantoin particulates of this invention are highly efficacious for the delivery of nitrofurantoin in oral dosage forms.

摘要翻译： 呋喃妥因颗粒包含离散的呋喃妥因颗粒，其中：（a）所述颗粒大于约200目尺寸; 和（b）所述颗粒的BET表面积为至少约0.2M 2 / g。 优选地，所述颗粒的表面基本上由呋喃妥因一水合物组成。 还优选地，所述颗粒包含至少约5％，更优选至少约50％的呋喃妥因一水合物。 本发明优选的组合物在水悬浮液中包含这些呋喃妥因颗粒。 本发明的呋喃妥因颗粒对口服剂型中呋喃妥因的输送是非常有效的。