发明公开
EP0415304A2 Dipyrido[3,2-b:2',3'-e][1,4]oxazepin (and thiazepin)-6(5H)-ones and their use in the prevention or treatment of aids
失效
Dipyrido¬3,2-B：2”，3'-E¬1,4氧氮杂，（和硫氮杂）-6（5H） - 酮类及其对艾滋病的预防或治疗
- 专利标题： Dipyrido[3,2-b:2',3'-e][1,4]oxazepin (and thiazepin)-6(5H)-ones and their use in the prevention or treatment of aids
- 专利标题（中）： Dipyrido¬3,2-B：2”，3'-E¬1,4氧氮杂，（和硫氮杂）-6（5H） - 酮类及其对艾滋病的预防或治疗
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申请号： EP90116338.6申请日： 1990-08-27
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公开(公告)号： EP0415304A2公开(公告)日： 1991-03-06
- 发明人: Hargrave, Karl D. Dr.
- 申请人： BOEHRINGER INGELHEIM PHARMACEUTICALS INC.
- 申请人地址： 900 Ridgebury Road, P.O. Box 368 Ridgefield, Connecticut 06877-0368 US
- 专利权人： BOEHRINGER INGELHEIM PHARMACEUTICALS INC.
- 当前专利权人： BOEHRINGER INGELHEIM PHARMACEUTICALS INC.
- 当前专利权人地址： 900 Ridgebury Road, P.O. Box 368 Ridgefield, Connecticut 06877-0368 US
- 代理机构： Laudien, Dieter, Dr.
- 优先权： US399802 19890829; US510642 19900418
- 主分类号： C07D498/14
- IPC分类号： C07D498/14 ; A61K31/55 ; C07D513/14
摘要：
Disclosed are dipyrido[3,2-b:2′,3′-e][1,4]oxazepin (and thiazepin)-6(5H)-ones and -thiones of formula
wherein,
X is oxygen or sulfur;
Z is oxygen or sulfur;
R¹ is alkyl, cycloalkyl, fluoroalkylmethyl, mono- or dihaloalkenyl, alkenyl or alkynyl, alkyloxyalkyl or alkylthioalkyl, aminocarbonylmethyl, acetyl, cyanoalkyl or hydroxyalkylmethyl. These are useful in the prevention or treatment of AIDS.
wherein,
X is oxygen or sulfur;
Z is oxygen or sulfur;
R¹ is alkyl, cycloalkyl, fluoroalkylmethyl, mono- or dihaloalkenyl, alkenyl or alkynyl, alkyloxyalkyl or alkylthioalkyl, aminocarbonylmethyl, acetyl, cyanoalkyl or hydroxyalkylmethyl. These are useful in the prevention or treatment of AIDS.
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