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1.发明授权Pyrimidinderivate, Arzneimittel enthaltend diese Verbindungen, deren Verwendung und Verfahren zu ihrer Herstellung 有权嘧啶衍生物，包含这些化合物，它们的用途和它们的制备方法的药物
公开(公告)号：EP2090571B1
公开(公告)日：2012-05-16
申请号：EP08163784.5
申请日：2002-10-14
申请人： Boehringer Ingelheim Pharma GmbH & Co. KG , Boehringer Ingelheim Pharmaceuticals, Inc. , BOEHRINGER INGELHEIM INTERNATIONAL GMBH
发明人： Dahmann, Georg , Himmelsbach, Frank , Wittneben, Helmut , Pautsch, Alexander , Prokopowicz, Anthony S. , Krist, Bernd , Schnapp, Gisela , Steegmaier, Martin , Lenter, Martin , Schoop, Andreas , Steurer, Steffen , Spevak, Walter
IPC分类号： C07D239/48 , C07D403/12 , C07D471/04 , C07D401/12 , C07D413/12 , A61K31/505 , A61K31/506 , A61P35/00 , C07D235/00 , C07D221/00
CPC分类号： C07D239/48 , C07D231/12 , C07D233/56 , C07D239/50 , C07D239/80 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/04 , C07D451/04 , C07D451/06 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10
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2.发明授权A NEW CLASS OF SURFACTANT-LIKE MATERIALS COMPRISING VITAMIN E TPGS AND A WATER SOLUBLE POLYMER 无效维生素E TPGS和水的聚合物为SURFUCTANTÄHNLICHEN材料的新类
公开(公告)号：EP1799194B1
公开(公告)日：2011-11-16
申请号：EP05813897.5
申请日：2005-09-16
IPC分类号： A61K9/14
CPC分类号： A61K31/355 , A61K9/146 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K47/22 , A61K47/32
摘要： This invention generally refers to a novel class of surfactant-like material comprising vitamin E TPGS and a water soluble polymer that promotes the solubility of poorly soluble compounds.
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公开(公告)号：EP1786801B1
公开(公告)日：2010-03-10
申请号：EP05786424.1
申请日：2005-08-23
发明人： GAO, Donghong , Boehringer Ingelheim Pharma., Inc. , MOSS, Neil, Boehringer Ingelheim Pharma. Inc. , WANG, Ji, Boehringer Ingelheim Pharma.Inc , WU, Jiang-Ping, Boehringer Ingelheim Pharma. Inc. , WU, Lifen, Boehringer Ingelheim Pharma. Inc. , XIONG, Zhaoming, Boehringer Ingelheim Pharma. Inc.
IPC分类号： C07D401/06 , A61K31/404 , C07D403/06 , A61K31/4453 , C07D405/06 , A61K31/496 , C07D413/06 , A61P29/00
CPC分类号： C07D487/04 , C07D209/10 , C07D209/42 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/12 , C07D413/06 , C07D417/06 , C07D487/08
摘要： Disclosed are compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
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公开(公告)号：EP1401409B1
公开(公告)日：2010-03-03
申请号：EP02732063.9
申请日：2002-06-11
CPC分类号： A61K9/0075 , Y10T428/2984
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5.发明公开Pyrimidinderivate, Arzneimittel enthaltend diese Verbindungen, deren Verwendung und Verfahren zu ihrer Herstellung 有权嘧啶衍生物，包含这些化合物，它们的用途和它们的制备方法的药物
公开(公告)号：EP2090571A1
公开(公告)日：2009-08-19
申请号：EP08163784.5
申请日：2002-10-14
申请人： Boehringer Ingelheim Pharma GmbH & Co. KG , Boehringer Ingelheim Pharmaceuticals, Inc. , BOEHRINGER INGELHEIM INTERNATIONAL GMBH
发明人： Dahmann, Georg , Himmelsbach, Frank , Wittneben, Helmut , Pautsch, Alexander , Prokopowicz, Anthony S. , Krist, Bernd , Schnapp, Gisela , Steegmaier, Martin , Lenter, Martin , Schoop, Andreas , Steurer, Steffen , Spevak, Walter
IPC分类号： C07D239/48 , C07D403/12 , C07D471/04 , C07D401/12 , C07D413/12 , A61K31/505 , A61K31/506 , A61P35/00 , C07D235/00 , C07D221/00
CPC分类号： C07D239/48 , C07D231/12 , C07D233/56 , C07D239/50 , C07D239/80 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/04 , C07D451/04 , C07D451/06 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10
摘要： Die vorliegende Erfindung betrifft trisubstituierte Pyrimidine der Formel (I)
worin
R a bis R e wie im Anspruch 1 definiert sind, welche zur Behandlung von Krankheiten, die durch exzessive oder anomale Zellproliferation charakterisiert sind, geeignet sind, deren Verwendung zur Herstellung eines Arzneimittels mit den vorstehend erwähnten Eigenschaften, und Verfahren zu ihrer Herstellung.摘要翻译： 本发明涉及三取代的式（I），其中R如权利要求1中限定的至R E，其适合于治疗疾病为特征的过度或异常细胞增殖的嘧啶，它们的使用用于制备具有所述的药物组合物 上述特征，以及它们的制备方法。
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6.发明授权3-[4-HETEROCYCLYL-1,2,3-TRIAZOL-1-YL]-N-ARYL-BENZAMIDES AS INHIBITORS OF THE CYTOKINES PRODUCTION FOR THE TREATMENT OF CHRONIC INFLAMMATORY DISEASES 有权3- [4 - 杂环基-1,2,3-三唑-1-基] -N- ARYLBENZAMIDE AS CYTOKINENPRODUKTION治疗慢性炎性疾病的治疗抑制剂
公开(公告)号：EP1725544B1
公开(公告)日：2009-05-27
申请号：EP05724523.5
申请日：2005-03-04
发明人： COGAN, Derek; Boehringer Ingelheim Pharm., Inc. , HAO, Ming-Hong, Boehringer Ingelheim Pharm., Inc. , KAMHI, Victor Marc , MILLER, Craig A., Boehringer Ingelheim Pharm. Inc. , NETHERTON, M. R., Boehringer Ingelheim Pharm. Inc. , SWINAMER, Alan D., Boehringer Ingelheim Pharm. Inc
IPC分类号： C07D403/04 , C07D401/14 , C07D401/04 , C07D405/04 , C07D417/04 , A61K31/4192 , A61P29/00
CPC分类号： C07D417/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D471/04 , C07D487/04 , C07D487/10 , C07D513/04
摘要： Disclosed compounds of formula (I), which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
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公开(公告)号：EP2008654A1
公开(公告)日：2008-12-31
申请号：EP08164478.3
申请日：2003-06-03
IPC分类号： A61K31/38 , A61K31/435 , C07D495/04 , A61P29/00 , C07D333/00 , C07D221/00
CPC分类号： C07D495/04 , A61K31/38 , A61K31/435 , C08G63/6956 , C08G63/916
摘要： Disclosed are compounds of formula (I):
wherein R 1 and R 2 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.摘要翻译： 公开了式（I）的化合物：其中R 1和R 2在本文中定义，其可用作IκB激酶（IKK）复合物的激酶活性的抑制剂。 因此，该化合物可用于治疗IKK介导的疾病，包括自身免疫性疾病炎性疾病和癌症。 还公开了包含这些化合物的药物组合物和制备这些化合物的方法。
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8.发明授权
公开(公告)号：EP1395227B1
公开(公告)日：2008-05-28
申请号：EP02746437.9
申请日：2002-05-23
发明人： LI, Jun , LI, Xiang, John , BARTON, Randall
IPC分类号： C12Q1/48
CPC分类号： C12Q1/485 , A61K38/00 , G01N33/6893 , G01N2333/9121 , G01N2500/00 , G01N2500/10 , G01N2500/20 , G01N2800/065 , G01N2800/52
摘要： Methods for the diagnosis of inflammatory bowel diseases and the identification of agents useful in the treatment of such diseases based upon the agent's effect on reducing Pim-2 expression. Figure 6 shows that Pim-2 is required for TNF-alpha-induced IL-6 expression in HeLa cells.
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9.发明授权NUCLEIC ACID CONSTRUCTS USEFUL FOR GLUCOSE REGULATED PRODUCTION OF HUMAN INSULIN IN SOMATIC CELL LINES 有权葡萄糖调控人胰岛素生产体细胞系SUITABLE NUCLEIC构建体
公开(公告)号：EP1458240B1
公开(公告)日：2008-04-30
申请号：EP02741943.1
申请日：2002-06-10
发明人： TATAKE, Revati J., Boehringer Ingelheim Corp. , SCHNEIDERMAN, Richard, Boehringer Ingelheim Corp. , BARTON, Randall Wilber, Boehringer Ingelheim, Corp
IPC分类号： A01N63/00 , A61K48/00 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74 , C12N15/85 , C12N15/87 , A61P5/48
CPC分类号： C07K14/62 , A61K35/12 , A61K48/00 , C12N2510/02
摘要： Unique multifunctional nucleotide expression cassettes comprising a nucleotide sequence encoding a human protease driven by a glucose-regulatable promoter, a nucleotide sequence encoding human proinsulin having sites at its B-C and C-A junctions altered to permit cleavage by the human protease, and a CMV promoter driving the transcription of the nucleotide sequence encoding the human proinsulin, such cassettes optionally having polyadenylation sequences after each structural gene and the nucleotide sequence encoding human proinsulin optionally carrying an H10D variant, and cells transformed thereby.
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10.发明授权FORMULATION FOR A METERED DOSE INHALER USING HYDRO-FLUORO-ALKANES AS PROPELLANTS 有权公式的计量吸入器，使用氢氟烷烃作为燃料
公开(公告)号：EP1608336B1
公开(公告)日：2008-03-26
申请号：EP04757846.3
申请日：2004-03-19
发明人： DESTEFANO, George, Boehringer Ingelheim Pharma Inc , KELASH-CANNAVO, Linda, Jean, Boehringer Ingelheim Pharma Inc
IPC分类号： A61K9/10
CPC分类号： A61K9/008
摘要： An improved suspension formulation for use in a metered-dose inhaler having a hydro-fluoro-alkane propellant is described, the improvement being the controlled addition of a small quantity of water.
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