In the driving mechanism for driving spindles of a ring spinning frame, wherein spindle alignments of the R side and the L side thereof are divided into a plurality of sub-unit groups (U) of spindles respectively so that a plurality of unit groups of spindles are formed along the lengthwise direction thereof by pairs of sub unit groups of spindles, each pair of sub-unit groups of spindles consist of a sub-unit group of spindles of R side, and a sub-unit group of spindles of L side which faces the sub-unit group of spindles of R side, a plurality of unit driving mechanisms (M) are formed along the lengthwise direction thereof to drive the corresponding one of the above-mentioned plurality of the unit groups of spindles respectively, spindles of each unit driving mechanism are driven by a single spindle tape (V), and the spindle tape is driven by a driving motor (M), and such improvement is applied so that the spindle tape is driven by the driving motor by way of at least two driving wheels (6), and the number of spindles per one driving wheel is less than six.