发明公开
EP0418071A3 New N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase
失效
作为ACYL COENZYME A的抑制剂的新型N-亚芳基和N-异丁酰胺和尿素衍生物A：胆固醇ACYL转移
- 专利标题： New N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase
- 专利标题（中）： 作为ACYL COENZYME A的抑制剂的新型N-亚芳基和N-异丁酰胺和尿素衍生物A：胆固醇ACYL转移
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申请号： EP90310009.7申请日： 1990-09-13
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公开(公告)号： EP0418071A3公开(公告)日： 1992-03-25
- 发明人: McCarthy, Peter A. , Walker, Frederick J. , Truong, Thien , Hamanaka, Ernest S. , Chang, George
- 申请人： PFIZER INC.
- 申请人地址： 235 East 42nd Street New York, N.Y. 10017 US
- 专利权人： PFIZER INC.
- 当前专利权人： PFIZER INC.
- 当前专利权人地址： 235 East 42nd Street New York, N.Y. 10017 US
- 代理机构： Moore, James William, Dr.
- 优先权： PCT/US89/04033 19890915
- 主分类号： C07C323/60
- IPC分类号： C07C323/60 ; C07D239/58 ; C07D213/75 ; C07D213/70 ; C07C323/52 ; A61K31/16 ; A61K31/33 ; C07D307/64 ; C07D277/74 ; C07D277/36 ; C07D215/36
摘要：
Compounds of the formula
the pharmaceutically acceptable salts thereof, wherein Q and R¹ are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.
the pharmaceutically acceptable salts thereof, wherein Q and R¹ are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.
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