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公开(公告)号：EP0210044A3
公开(公告)日：1987-10-21
申请号：EP86305466
申请日：1986-07-16
申请人： PFIZER INC.
IPC分类号： C07D239/46 , C07D405/04 , C07D409/04 , A61K31/505
CPC分类号： C07D239/47 , C07D405/04 , C07D409/04
摘要： 2-Amino-4-substituted-5-(hydroxy or alkoxy)-pyrimidines, which may be 6-substituted, and derivatives thereof are inhibitors of leukotriene synthesis and are therefore useful for the treatment of pulmonary, inflammatory, allergic and cardiovascular diseases. The compounds are also cytoprotective and therefore useful in the treatment of peptic ulcers.
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公开(公告)号：EP0210044B1
公开(公告)日：1990-08-29
申请号：EP86305466.4
申请日：1986-07-16
申请人： PFIZER INC.
IPC分类号： C07D239/46 , C07D405/04 , C07D409/04 , A61K31/505
CPC分类号： C07D239/47 , C07D405/04 , C07D409/04
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3.发明授权New N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase 失效N-芳基和N- heteroarylamides和尿素衍生物为酰基辅酶A的抑制剂：胆固醇酰基转移酶。
公开(公告)号：EP0418071B1
公开(公告)日：1995-04-26
申请号：EP90310009.7
申请日：1990-09-13
申请人： PFIZER INC.
发明人： McCarthy, Peter A. , Walker, Frederick J. , Truong, Thien , Hamanaka, Ernest S. , Chang, George
IPC分类号： C07C323/60 , C07D239/58 , C07D213/75 , C07D213/70 , C07C323/52 , A61K31/16 , A61K31/33 , C07D307/64 , C07D277/74 , C07D277/36 , C07D215/36
CPC分类号： C07D213/70 , C07C317/44 , C07C323/52 , C07C323/60 , C07D213/75 , C07D215/36 , C07D215/38 , C07D215/40 , C07D217/02 , C07D235/28 , C07D237/28 , C07D237/30 , C07D239/48 , C07D239/50 , C07D239/52 , C07D239/56 , C07D239/58 , C07D239/60 , C07D239/74 , C07D277/36 , C07D277/74 , C07D307/64 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04
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公开(公告)号：EP0210044A2
公开(公告)日：1987-01-28
申请号：EP86305466.4
申请日：1986-07-16
申请人： PFIZER INC.
IPC分类号： C07D239/46 , C07D405/04 , C07D409/04 , A61K31/505
CPC分类号： C07D239/47 , C07D405/04 , C07D409/04
摘要： 2-Amino-4-substituted-5-(hydroxy or alkoxy)-pyrimidines, which may be 6-substituted, and derivatives thereof are inhibitors of leukotriene synthesis and are therefore useful for the treatment of pulmonary, inflammatory, allergic and cardiovascular diseases. The compounds are also cytoprotective and therefore useful in the treatment of peptic ulcers.
摘要翻译： 可以是6-取代的2-氨基-4-取代-5-（羟基或烷氧基）嘧啶及其衍生物是白细胞三烯合成的抑制剂，因此可用于治疗肺，炎症，变态反应和心血管疾病。 化合物也是细胞保护性的，因此可用于治疗消化性溃疡。
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5.发明授权New N-heteroarylamide derivatives as inhibitors of acyl coenzyme A: cholestrol acyl transferase 失效的N- Heteroarylamidederivate作为酰基辅酶A的抑制剂：胆固醇酰基转移酶
公开(公告)号：EP0609960B1
公开(公告)日：1999-03-03
申请号：EP94200437.5
申请日：1990-09-13
申请人： PFIZER INC.
发明人： McCarthy, Peter A. , Hamanaka, Ernest S. , Walker, Frederick J. , Chang, George , Truong, Thien
IPC分类号： C07D213/75 , A61K31/44 , C07D239/52 , C07D239/58 , A61K31/505
CPC分类号： C07D213/70 , C07C317/44 , C07C323/52 , C07C323/60 , C07D213/75 , C07D215/36 , C07D215/38 , C07D215/40 , C07D217/02 , C07D235/28 , C07D237/28 , C07D237/30 , C07D239/48 , C07D239/50 , C07D239/52 , C07D239/56 , C07D239/58 , C07D239/60 , C07D239/74 , C07D277/36 , C07D277/74 , C07D307/64 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04
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6.发明公开New N-heteroarylamide derivatives as inhibitors of acyl coenzyme A: cholestrol acyl transferase 失效N-Heteroarylamidederivate als Inhibitoren von Acyl-Coenzym A：Cholesterol-Acyl-Transférase。
公开(公告)号：EP0609960A1
公开(公告)日：1994-08-10
申请号：EP94200437.5
申请日：1990-09-13
申请人： PFIZER INC.
发明人： McCarthy, Peter A. , Hamanaka, Ernest S. , Walker, Frederick J. , Chang, George , Truong, Thien
IPC分类号： C07D213/75 , A61K31/44 , C07D239/52 , C07D239/58 , A61K31/505
CPC分类号： C07D213/70 , C07C317/44 , C07C323/52 , C07C323/60 , C07D213/75 , C07D215/36 , C07D215/38 , C07D215/40 , C07D217/02 , C07D235/28 , C07D237/28 , C07D237/30 , C07D239/48 , C07D239/50 , C07D239/52 , C07D239/56 , C07D239/58 , C07D239/60 , C07D239/74 , C07D277/36 , C07D277/74 , C07D307/64 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04
摘要： Compounds of the formula
the pharmaceutically acceptable salts thereof, wherein Q is a substituted pyridine or pyrimidine group and R¹ incorporates a hydrocarbon group of from 4 to 16 carbon atoms, are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.摘要翻译： 式（CHEM）其药学上可接受的盐，其中Q为取代的吡啶或嘧啶基团，R 1为含有4至16个碳原子的烃基，为酰基辅酶A：胆固醇酰基转移酶（ACAT） ），可用作降血脂和抗动脉粥样硬化剂。
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7.发明公开New N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase 失效作为ACYL COENZYME A的抑制剂的新型N-亚芳基和N-异丁酰胺和尿素衍生物A：胆固醇ACYL转移
公开(公告)号：EP0418071A3
公开(公告)日：1992-03-25
申请号：EP90310009.7
申请日：1990-09-13
申请人： PFIZER INC.
发明人： McCarthy, Peter A. , Walker, Frederick J. , Truong, Thien , Hamanaka, Ernest S. , Chang, George
IPC分类号： C07C323/60 , C07D239/58 , C07D213/75 , C07D213/70 , C07C323/52 , A61K31/16 , A61K31/33 , C07D307/64 , C07D277/74 , C07D277/36 , C07D215/36
CPC分类号： C07D213/70 , C07C317/44 , C07C323/52 , C07C323/60 , C07D213/75 , C07D215/36 , C07D215/38 , C07D215/40 , C07D217/02 , C07D235/28 , C07D237/28 , C07D237/30 , C07D239/48 , C07D239/50 , C07D239/52 , C07D239/56 , C07D239/58 , C07D239/60 , C07D239/74 , C07D277/36 , C07D277/74 , C07D307/64 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04
摘要： Compounds of the formula
the pharmaceutically acceptable salts thereof, wherein Q and R¹ are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.-
8.发明公开New N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase 失效N-芳基和N-杂芳基酰胺和Harnstoffderivate als Inhibitoren von Acyl-Coenzym A：Cholesterol-Acyl-Transferase。
公开(公告)号：EP0418071A2
公开(公告)日：1991-03-20
申请号：EP90310009.7
申请日：1990-09-13
申请人： PFIZER INC.
发明人： McCarthy, Peter A. , Walker, Frederick J. , Truong, Thien , Hamanaka, Ernest S. , Chang, George
IPC分类号： C07C323/60 , C07D239/58 , C07D213/75 , C07D213/70 , C07C323/52 , A61K31/16 , A61K31/33 , C07D307/64 , C07D277/74 , C07D277/36 , C07D215/36
CPC分类号： C07D213/70 , C07C317/44 , C07C323/52 , C07C323/60 , C07D213/75 , C07D215/36 , C07D215/38 , C07D215/40 , C07D217/02 , C07D235/28 , C07D237/28 , C07D237/30 , C07D239/48 , C07D239/50 , C07D239/52 , C07D239/56 , C07D239/58 , C07D239/60 , C07D239/74 , C07D277/36 , C07D277/74 , C07D307/64 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04
摘要： Compounds of the formula
the pharmaceutically acceptable salts thereof, wherein Q and R¹ are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.摘要翻译： 其中Q和R 1定义如下的式
其药学上可接受的盐，以及用于合成这些化合物的新型羧酸和酰卤中间体。 式I化合物是酰基辅酶A：胆固醇酰基转移酶（ACAT）的抑制剂，可用作降血脂和抗动脉粥样硬化剂。
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