发明授权
- 专利标题： RECOMBINANT TECHNIQUES FOR PRODUCTION OF NOVEL NATRIURETIC AND VASODILATOR PEPTIDES
- 专利标题（中）： 重组技术用于新的生产和利钠肽血管舒张。
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申请号： EP89906935.5申请日： 1989-05-31
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公开(公告)号： EP0418308B1公开(公告)日： 1995-08-16
- 发明人: SEILHAMER, J., Jeffrey , LEWICKI, John , SCARBOROUGH, Robert, M. , PORTER, J., Gordon
- 申请人： SCIOS NOVA INC.
- 申请人地址： 2450 Bayshore Parkway Mountain View, CA 94043 US
- 专利权人： SCIOS NOVA INC.
- 当前专利权人： SCIOS NOVA INC.
- 当前专利权人地址： 2450 Bayshore Parkway Mountain View, CA 94043 US
- 代理机构： Goldin, Douglas Michael
- 优先权： US200383 19880531; US206470 19880614; US299880 19890119
- 国际公布： WO8912069 19891214
- 主分类号： C07K14/00
- IPC分类号： C07K14/00 ; C12P21/00 ; C12N15/00 ; C07H15/12 ; A61K38/46
摘要：
The cDNA sequence encoding porcine brain natriuretic peptide and related genes encoding canine and human peptides with natriuretic activity are disclosed. The gene is shown to make accessible the DNAs encoding analogous natriuretic peptides in other vertebrate species. The genes encoding these NPs can be used to effect modifications of the sequence to produce alternate forms of the NPs and to provide practical amounts of these proteins. The NPs of the invention can also be synthesized chemically.
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