公开(公告)号：EP0418308B1

公开(公告)日：1995-08-16

申请号：EP89906935.5

申请日：1989-05-31

申请人： SCIOS NOVA INC.

发明人： SEILHAMER, J., Jeffrey ,  LEWICKI, John ,  SCARBOROUGH, Robert, M. ,  PORTER, J., Gordon

IPC分类号： C07K14/00 ,  C12P21/00 ,  C12N15/00 ,  C07H15/12 ,  A61K38/46

CPC分类号： C12P21/02 ,  A61K38/00 ,  C07K14/58 ,  C07K14/582 ,  C07K16/241 ,  C07K16/2803 ,  C07K2317/622 ,  G01N33/74

摘要： The cDNA sequence encoding porcine brain natriuretic peptide and related genes encoding canine and human peptides with natriuretic activity are disclosed. The gene is shown to make accessible the DNAs encoding analogous natriuretic peptides in other vertebrate species. The genes encoding these NPs can be used to effect modifications of the sequence to produce alternate forms of the NPs and to provide practical amounts of these proteins. The NPs of the invention can also be synthesized chemically.