发明公开
- 专利标题： Phenoxy-heterocyclic compounds
- 专利标题（中）： 苯氧基 - 杂环化合物
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申请号： EP90120052.7申请日： 1990-10-19
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公开(公告)号： EP0423802A1公开(公告)日： 1991-04-24
- 发明人: Freedman, Jules , Dudley, Mark W.
- 申请人： MERRELL DOW PHARMACEUTICALS INC.
- 申请人地址： 2110 East Galbraith Road, P.O. Box 156300 Cincinnati Ohio 45215-6300 US
- 专利权人： MERRELL DOW PHARMACEUTICALS INC.
- 当前专利权人： MERRELL DOW PHARMACEUTICALS INC.
- 当前专利权人地址： 2110 East Galbraith Road, P.O. Box 156300 Cincinnati Ohio 45215-6300 US
- 代理机构： VOSSIUS & PARTNER
- 优先权： US424429 19891020
- 主分类号： C07D233/22
- IPC分类号： C07D233/22 ; A61K31/415 ; C07D405/06 ; C07D405/12 ; C07D239/06 ; A61K31/505 ; A61K31/36
摘要：
The present invention is directed to a class of phenoxy-heterocyclic compounds of the formula I:
in which R₁ is represented by hydrogen, halogen, alkyl, alkoxy, OH, CF₃, CN, methylenedioxy, ethylenedioxy, methylene, 2,3-benzo, 3,4-benzo, alkylthio, alkylsulfonyl, alkylsulfinyl, cycloalkyl, cycloalkoxy or cycloalkylthio; R₂ is represented by halogen, alkyl, alkoxy, OH, CF₃, CN, alkylthio, alkylsulfinyl, cycloalkyl, cycloalkoxy or cycloalkylthio; R₃ is represented by hydrogen, halogen, alkyl, alkoxy, OH, CF₃, CN, methylenedioxy, ethylenedioxy, methylene, 2,3-benzo, 3,4-benzo, 4,5-benzo, 5,6-benzo, alkylthio, alkylsulfonyl, alkylsulfinyl, cycloalkyl, cycloalkoxy or cycloalkylthio; m is represented by the integer 1 or 2; p is represented by an integer from 0-4; and the pharmaceutically acceptable addition salts thereof, and to their use as anti-depressants, anxiolytics and anti-hypertensive agents.
in which R₁ is represented by hydrogen, halogen, alkyl, alkoxy, OH, CF₃, CN, methylenedioxy, ethylenedioxy, methylene, 2,3-benzo, 3,4-benzo, alkylthio, alkylsulfonyl, alkylsulfinyl, cycloalkyl, cycloalkoxy or cycloalkylthio; R₂ is represented by halogen, alkyl, alkoxy, OH, CF₃, CN, alkylthio, alkylsulfinyl, cycloalkyl, cycloalkoxy or cycloalkylthio; R₃ is represented by hydrogen, halogen, alkyl, alkoxy, OH, CF₃, CN, methylenedioxy, ethylenedioxy, methylene, 2,3-benzo, 3,4-benzo, 4,5-benzo, 5,6-benzo, alkylthio, alkylsulfonyl, alkylsulfinyl, cycloalkyl, cycloalkoxy or cycloalkylthio; m is represented by the integer 1 or 2; p is represented by an integer from 0-4; and the pharmaceutically acceptable addition salts thereof, and to their use as anti-depressants, anxiolytics and anti-hypertensive agents.
公开/授权文献
- EP0423802B1 Phenoxy-heterocyclic compounds 公开/授权日：1995-08-09
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