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11 条记录 (耗时 0.014 秒)

    2H-(1) benzoxepino (5,4-b)-1,4 oxazine derivatives
    4.
    发明公开
    2H-(1) benzoxepino (5,4-b)-1,4 oxazine derivatives 失效
    2H-（1）苯并氧杂（5,4-b）的-1,4- oxazinderivate。

    公开(公告)号：EP0116372A1

    公开(公告)日：1984-08-22

    申请号：EP84101519.1

    申请日：1984-02-14

    申请人： MERRELL DOW PHARMACEUTICALS INC.

    发明人： Freedman, Jules

    IPC分类号： C07D498/04 ,  A61K31/535

    CPC分类号： C07D313/08

    摘要： Derivatives of 2H-[1]benzoxepino[5,4-b]-1,4-oxazine, such as (4a,11b)-3,4,4a,5,6,11b-hexahydro-2H-[1]benzoxepino[5,4-b]-1,4-oxazine, are prepared by acylating a 4-amino-2,3,4,5-tetrahydro-1-benzoxepin-5-ol, cyclizing the resulting chloroacetamido alcohol, reducing the 1,4-oxazine-3(4H)-one so obtained, acylating the resulting 2H-[1]benzoxepino[5,4-b]-1,4-oxazine, and reducing the N-acyl-2H-[1]benzoxepino[5,4-b]-1,4-oxazine so obtained. The novel compounds disclosed herein possess useful muscle relaxant and analgesic properties.

    摘要翻译： 2H- [1]苯并氧杂ino [5,4-b] -1,4-恶嗪衍生物，如（4a，11b）-3,4,4a，5,6,11b-六氢-2H- [1]苯并氧杂ino [5,4-b] -1,4-恶嗪通过酰化4-氨基-2,3,4,5-四氢-1-苯并氧杂七环-5-醇制备，环化所得氯乙酰胺醇，还原1 ，4-恶嗪-3（4H） - 酮，酰化所得的2H- [1]苯并氧杂环[5,4-b] -1,4-恶嗪，还原N-酰基-2H- [1]苯并氧杂ino [5,4-b] -1,4-恶嗪。 本文公开的新颖化合物具有有用的肌肉松弛剂和镇痛特性。

    2H-(1) benzoxepino(5,4-b)-1,4-oxazine derivatives
    7.
    发明公开
    2H-(1) benzoxepino(5,4-b)-1,4-oxazine derivatives 失效
    2H-（1）苯并氧杂庚因（5,4-b）-1,4-恶嗪衍生物

    公开(公告)号：EP0116373A1

    公开(公告)日：1984-08-22

    申请号：EP84101520.9

    申请日：1984-02-14

    申请人： MERRELL DOW PHARMACEUTICALS INC.

    发明人： Freedman, Jules ,  Dage, Richard C.

    IPC分类号： C07D498/04 ,  C07D498/14 ,  A61K31/535

    CPC分类号： C07D313/08

    摘要： Derivates of 2H-[1]benzoxepino[5,4-b]-1,4-oxazine, such as trans-(4a, 11b)-3,4,4a,5,6,11b-hexahydro-10-methoxy-2H [1]benzoxepino[5,4-b]-1,4-oxazine, are prepared by acylating a trans-4-amino-2,3,4,5-tetrahydro-1-benzoxepin-5-ol, cyclizing the resulting chloroacetamido alcohol, reducing the 1,4-oxazine-3(4H)-one so obtained, acylating the resulting 2H-[1]benzoxepino[5,4-b]-1,4-oxazine, and reducing the N-acyl-2H-[1]benzoxepino[5,4,-b]-1,4-oxazine so obtained. The novel compounds disclosed herein possess useful antihypertensive properties.

    摘要翻译： 2H- [1]苯并氧杂庚英并[5,4-b] -1,4-恶嗪的衍生物，如反式 - （4a，11b）-3,4,4a，5,6,11b-六氢-10-甲氧基 - 2H [1]苯并氧杂庚英并[5,4-b] -1,4-恶嗪，通过酰化反式-4-氨基-2,3,4,5-四氢-1-苯并氧杂七环-5-醇， 得到氯乙酰胺醇，还原如此得到的1,4-恶嗪-3（4H） - 酮，酰化得到的2H- [1]苯并氧杂庚英并[5,4-b] -1,4-恶嗪，还原N-酰基 -2H- [1]苯并氧杂庚英并[5,4-b] -1,4-恶嗪。 本文公开的新化合物具有有用的抗高血压性质。

    Phenoxy-heterocyclic compounds
    10.
    发明公开
    Phenoxy-heterocyclic compounds 失效
    苯氧基 - 杂环化合物

    公开(公告)号：EP0423802A1

    公开(公告)日：1991-04-24

    申请号：EP90120052.7

    申请日：1990-10-19

    申请人： MERRELL DOW PHARMACEUTICALS INC.

    发明人： Freedman, Jules ,  Dudley, Mark W.

    IPC分类号： C07D233/22 ,  A61K31/415 ,  C07D405/06 ,  C07D405/12 ,  C07D239/06 ,  A61K31/505 ,  A61K31/36

    CPC分类号： C07D239/06 ,  C07D233/22 ,  C07D405/06 ,  C07D405/12

    摘要： The present invention is directed to a class of phenoxy-heterocyclic compounds of the formula I:
    in which R₁ is represented by hydrogen, halogen, alkyl, alkoxy, OH, CF₃, CN, methylenedioxy, ethylenedioxy, methylene, 2,3-benzo, 3,4-benzo, alkylthio, alkylsulfonyl, alkylsulfinyl, cycloalkyl, cycloalkoxy or cycloalkylthio; R₂ is represented by halogen, alkyl, alkoxy, OH, CF₃, CN, alkylthio, alkylsulfinyl, cycloalkyl, cycloalkoxy or cycloalkylthio; R₃ is represented by hydrogen, halogen, alkyl, alkoxy, OH, CF₃, CN, methylenedioxy, ethylenedioxy, methylene, 2,3-benzo, 3,4-benzo, 4,5-benzo, 5,6-benzo, alkylthio, alkylsulfonyl, alkylsulfinyl, cycloalkyl, cycloalkoxy or cycloalkylthio; m is represented by the integer 1 or 2; p is represented by an integer from 0-4; and the pharmaceutically acceptable addition salts thereof, and to their use as anti-­depressants, anxiolytics and anti-hypertensive agents.

    摘要翻译： 本发明涉及一类式I的苯氧基 - 杂环化合物：其中R 1由氢，卤素，烷基，烷氧基，OH，CF 3，CN，亚甲二氧基，亚乙二氧基，亚甲基，2,3-苯并三唑， 烷基硫基，烷基磺酰基，烷基亚磺酰基，环烷基，环烷氧基或环烷硫基; R 2由卤素，烷基，烷氧基，OH，CF 3，CN，烷硫基，烷基亚磺酰基，环烷基，环烷氧基或环烷硫基表示; R 3由氢，卤素，烷基，烷氧基，OH，CF 3，CN，亚甲二氧基，亚乙二氧基，亚甲基，2,3-苯并，3,4-苯并，4,5-苯并，5,6-苯并，烷硫基， 烷基磺酰基，烷基亚磺酰基，环烷基，环烷氧基或环烷硫基; m由整数1或2表示; p由0-4的整数表示; 及其药学上可接受的加成盐，以及它们作为抗抑郁药，抗焦虑药和抗高血压药的用途。