发明授权
- 专利标题： PROCEDE DE PREPARATION DE LA PROTEINE C ACTIVEE
- 专利标题（英）： Process for preparation of activated protein c
- 专利标题（中）： 用于生产活化蛋白C.
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申请号： EP90907093.0申请日： 1990-04-10
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公开(公告)号： EP0424498B1公开(公告)日： 1994-06-08
- 发明人: STEINBUCH, Marion , CHABBAT, Jacques , TABY, Olivier
- 申请人： FONDATION NATIONALE DE TRANSFUSION SANGUINE
- 申请人地址： 6, rue Alexandre Cabanel 75739 Paris Cédex 15 FR
- 专利权人： FONDATION NATIONALE DE TRANSFUSION SANGUINE
- 当前专利权人： FONDATION NATIONALE DE TRANSFUSION SANGUINE
- 当前专利权人地址： 6, rue Alexandre Cabanel 75739 Paris Cédex 15 FR
- 代理机构： Warcoin, Jacques
- 优先权： FR8904814 19890412; FR9002028 19900220
- 国际公布： WO9012028 19901018
- 主分类号： C07K3/20
- IPC分类号： C07K3/20 ; C12N9/64
摘要：
The present invention concerns a process for preparation of activated protein C (APC) on the basis of a sample containing said activated protein C, characterised by the fact that the activated protein C is fixed to aprotinine which has been rendered insoluble, and that after washing of said complex activated protein C-aprotinine with a neutralised saline solution, said activated protein C is recovered by elution with an acid aqueous solution or a solution containing a chaotropic agent. Said invention also relates to the activated protein C obtained according to the process described above.
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