公开(公告)号：EP2000537A3

公开(公告)日：2012-06-20

申请号：EP08164456.9

申请日：1998-06-22

申请人： Institut Pasteur

发明人： El Solh, Névine ,  Allignet, Jeanine

IPC分类号： C12N15/54 ,  C12N9/10 ,  C12N15/31 ,  C07K14/31 ,  C12N15/55 ,  C12N9/18 ,  C12N15/74 ,  C12N1/21 ,  C12Q1/14 ,  C12Q1/34 ,  C12Q1/48 ,  C12Q1/68 ,  G01N33/569 ,  C07K16/12 ,  C07K16/40 ,  C12N9/88

CPC分类号： C12N9/88 ,  C07K14/31 ,  C12N9/1029 ,  C12N9/18 ,  C12Q1/689 ,  C12Q2600/136 ,  Y10S435/975

摘要： The present invention pertains to polynucleotides derived from staphylococcal genes encoding resistance to streptogramin A or to streptogramin B and chemically related compounds. This invention also relates to the use of the polynucleotides as oligonucleotide primers or probes for detecting Staphylococcal strains that are resistant to streptogramin A or to streptogramin B and related compounds in a biological sample. In another embodiment, the present invention is directed to the full length coding sequences of the staphylococcal genes encoding for resistance to streptogramin A or to streptogramin B from Staphylococcus and to the polypeptides expressed by these full length coding sequences. Further, this invention relates to the use of the expressed polypeptides to produce specific monoclonal or polyclonal antibodies that serve as detection means in order to characterize any staphylococcal strain carrying genes encoding resistance to streptogramin A or to streptogramin B.

公开(公告)号：EP2134681B1

公开(公告)日：2012-05-16

申请号：EP08718147.5

申请日：2008-03-21

申请人： Centre National de la Recherche Scientifique (CNRS) ,  Université de Montpellier I

发明人： MARTINEZ, Jean ,  DEWYNTER, Georges ,  FARRAN, Daniel

IPC分类号： C07D207/36 ,  C07D215/38 ,  C07D491/048

CPC分类号： C07D207/36 ,  C07D215/28 ,  C07D215/38 ,  C07D471/10 ,  C07D487/08 ,  C07D491/048 ,  Y02P20/55

摘要： The invention relates to a method for the synthesis of a compound of the following formula (I) in which: R1 and R2 are independently an N-protective group; R3 is a hydrogen atom, a C1-C6 alkyl group, a C1-C6 arylalkyl group, a C2-C6 alkenyl group, or a alkoxycarbonylalkyl group; Y is a -C(HR4)- group in which R4 is a hydrogen atom, a C1-C6 alkyl group, an aryl group, a C1-C6 arylalkyl group, or a C2-C6 alkenyl group; or an orthophenylene group.

公开(公告)号：EP1937249B1

公开(公告)日：2012-04-25

申请号：EP06793080.0

申请日：2006-08-30

申请人： Laboratoires Expanscience

发明人： MSIKA, Philippe ,  PICCARDI, Nathalie

IPC分类号： A61K31/34 ,  A61K8/49 ,  A61Q19/02

CPC分类号： A61K8/4973 ,  A61Q19/02

摘要： The invention concerns the cosmetic use of at least one 2-alkyl furan, as depigmenting active principle, in a depigmenting composition, as well as the associated cosmetic treatment method. The invention also concerns the use of at least one 2-alkyl furan for preparing an active drug as depigmenting agent. The invention further concerns a depigmenting cosmetic composition comprising as depigmenting active principle at least one 2-alkyl furan.

公开(公告)号：EP1613738B1

公开(公告)日：2012-04-11

申请号：EP04727007.9

申请日：2004-04-13

申请人： Lesaffre et Compagnie ,  Algist Bruggeman N.V.

发明人： SMET, Peter, René, Anna ,  BLOMME, Karel, Alfons, Frans ,  VAN EETVELDE, Gabriel, Petrus

IPC分类号： C12N1/18 ,  A21D8/04

CPC分类号： C12N1/16 ,  A21D8/047

摘要： The invention relates to active dry yeast which is packed in the form of a fermentation agent as a tablet containing active dry yeast.

公开(公告)号：EP1712245B1

公开(公告)日：2012-02-01

申请号：EP06112314.7

申请日：2006-04-06

申请人： Howmedica Osteonics Corp.

发明人： Murphy, Matthew E. ,  Cleere, Cillin P. ,  Hess, Brian J. ,  Insley, Gerard M. ,  Sun Wai, Adrian ,  O'Mahony, Donal ,  Higham, Paul

IPC分类号： A61L27/04 ,  A61L27/12

CPC分类号： A61L27/12 ,  A61L24/02 ,  A61L27/02 ,  A61L2430/02

公开(公告)号：EP1659858B1

公开(公告)日：2012-01-18

申请号：EP04744033.4

申请日：2004-07-05

申请人： INSTITUT PASTEUR

发明人： AURIAULT, Claude ,  PANCRE, Véronique ,  LONE, Yu-Chun ,  PAJOT, Anthony ,  LEMONNIER, François

IPC分类号： A01K67/027 ,  C07K14/705 ,  G01N33/50 ,  A61K49/00 ,  C12N5/10

CPC分类号： A01K67/0278 ,  A01K67/0275 ,  A01K67/0276 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/052 ,  A01K2217/054 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/03 ,  A61K49/0008 ,  C07K14/70539 ,  C12N15/8509

摘要： The present invention relates to transgenic mice and isolated transgenic mouse cells, the mice and mouse cells comprising a disrupted H2 class I gene, a disrupted H2 class II gene, a functional HLA class I transgene, and a functional HLA class II transgene. In embodiments, the transgenic mouse or mouse cells are deficient for both H2 class I and class II molecules, wherein the transgenic mouse comprises a functional HLA class I transgene and a functional HLA class II transgene. In embodiments, the transgenic mouse or mouse cell has the genotype HLA-A2+HLA-DR1+&bgr;2m°IA&bgr;°. The invention also relates to methods of using a transgenic mouse of the invention.

公开(公告)号：EP2390350A1

公开(公告)日：2011-11-30

申请号：EP10305563.8

申请日：2010-05-27

申请人： Centre National de la Recherche Scientifique (CNRS) ,  Ecole Normale Superieure (ENS)

发明人： Bensimon, David ,  Croquette, Vincent ,  Allemand, Jean-François ,  Manosas, Maria ,  Ding, Fang-Yuan

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6869 ,  C12Q1/6874 ,  C12Q2537/1376 ,  C12Q2525/204 ,  C12Q2523/305

摘要： The present invention relates to a method for the determination of a nucleic acid sequence by physical manipulation. The method is based on the precise determination of the localization of the replicating fork on the template by measuring the physical distance between one end of the molecule and the fork. This allows the determination of the physical location of the site where a pause or a blockage of the replication occurs, and deducing therefrom information on the sequence of the nucleic acid.

摘要翻译： 本发明涉及通过物理操作来测定核酸序列的方法。 该方法基于通过测量分子的一端和叉之间的物理距离来精确确定复制叉在模板上的定位。 这允许确定发生暂停或阻止复制的位点的物理位置，并从其中推导出关于核酸序列的信息。

公开(公告)号：EP1071710B2

公开(公告)日：2011-11-02

申请号：EP99913538.7

申请日：1999-04-15

申请人： Merck Serono Biodevelopment

发明人： BLUMENFELD, Marta ,  CHUMAKOV, Ilya ,  BOUGUELERET, Lydie

IPC分类号： C07K14/47 ,  C12N15/12 ,  C12Q1/68 ,  C07K16/18 ,  A01K67/027 ,  G06F17/30 ,  G06F17/50

CPC分类号： C12Q1/6883 ,  A01K2217/05 ,  A01K2217/075 ,  C07K14/4705 ,  C12Q1/6827 ,  C12Q2600/156

摘要： The invention concerns the genomic sequence of the FLAP gene. The invention also concerns biallelic markers of a FLAP gene and the association established between these markers and diseases involving the leukotriene pathway such as asthma. The invention provides means to determine the predisposition of individuals to diseases involving the leukotriene pathway as well as means for the diagnosis of such diseases and for the prognosis/detection of an eventual treatment response to agents acting on the leukotriene pathway.

公开(公告)号：EP2035442B1

公开(公告)日：2011-10-12

申请号：EP07765429.1

申请日：2007-06-14

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  Université de Montpellier I ,  Genepep

发明人： MARTINEZ, Jean ,  SUBRA, Gilles ,  CRISTAU, Michèle ,  CANTEL, Sonia

IPC分类号： C07K1/113 ,  C07K7/06

CPC分类号： C07K1/1133 ,  Y02P20/55 ,  Y02P20/582

摘要： The present invention relates to a supported oxidation reactant of formula (I): R-[Met(O)k]n-X- (I) in which: - R represents a hydrogen atom or an amine function-protecting group, -[Met(O)] represents an oxidized methionine residue of formula - k is 1 or 2 - represents a solid or soluble support used in organic synthesis, - X represents a radical derived from a function of the type amine or hydroxyl, or halogeno, capable of anchoring methionine, it being understood that this function capable of anchoring methionine can be separated from the support by means of a functionalized arm or a spacer, and - n is an integer greater than or equal to 1. The invention also relates to the use of a supported oxidation reactant of formula (I), for the formation of intramolecular disulfide bridges, in particular in peptides and/or proteins.

公开(公告)号：EP2091343B9

公开(公告)日：2011-09-28

申请号：EP07822640.4

申请日：2007-11-15

申请人： Compagnie Gervais Danone

发明人： RABAULT, Jean-Luc ,  LAMBERT, Flavien

IPC分类号： A23D7/005 ,  A23L1/064 ,  A23L1/212 ,  A23G1/48

CPC分类号： A23D7/0056 ,  A23G1/48 ,  A23L19/01 ,  A23L21/12

摘要： The invention relates to a fruit-based fatty stuffing or spread comprising a suspension of solid particles in a continuous fatty phase containing at least one sweetening agent in a amount lower than 45 wt %, less than 3 wt % and advantageously less 1 wt % of non fatty dried cocoa, and having a fatty material content of between 23 and 38 wt %, characterised in that it contains milk powder and/or dairy derivatives powder and/or dry starch and between 3 and 20 wt % of a fruit powder, the fruit powder having a D90 lower than 500 µm and a water content lower than 8 wt %, the content of (milk powder + diary derivatives powder + dry starch) being higher than 25 wt %. The invention further relates to a method for producing the fatty stuffing or spread and to the use thereof in a food product.