发明公开
- 专利标题: PHENYLALKANOYLAMINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USES
- 专利标题(中): 苯基甲酰胺衍生物,其制备方法及其用途
-
申请号: EP89905187.4申请日: 1989-05-01
-
公开(公告)号: EP0424528A1公开(公告)日: 1991-05-02
- 发明人: OGURA, Kuniyoshi, Zeria Pharmaceutical Co., Ltd. , AOTSUKA, Tomoji, Zeria Pharmaceutical Co., Ltd. , TORIZUKA, Motoki, Zeria Pharmaceutical Co., Ltd. , SOEDA, Mitsuo, Zeria Pharmaceutical Co., Ltd. , TANAKA, Yoshiaki, Zeria Pharmaceutical Co., Ltd. , KATO, Hisayoshi, Zeria Pharmaceutical Co., Ltd. , MIURA, Naoyoshi, Zeria Pharmaceutical Co., Ltd. , NAKATA, Naoki, Zeria Pharmaceutical Co., Ltd. , MORITA, Hikaru, Zeria Pharmaceutical Co., Ltd. , OKUBO, Akihiro, Zeria Pharmaceutical Co., Ltd.
- 申请人: ZERIA PHARMACEUTICAL CO., LTD.
- 申请人地址: 10-11, Nihonbashi Kobuna-cho Chuo-ku, Tokyo 103 JP
- 专利权人: ZERIA PHARMACEUTICAL CO., LTD.
- 当前专利权人: ZERIA PHARMACEUTICAL CO., LTD.
- 当前专利权人地址: 10-11, Nihonbashi Kobuna-cho Chuo-ku, Tokyo 103 JP
- 代理机构: Wächtershäuser, Günter, Prof. Dr.
- 优先权: JP112067/88 19880509; JP57865/89 19890313
- 国际公布: WO8910918 19891116
- 主分类号: C07D277/04
- IPC分类号: C07D277/04 ; C07D211/70 ; C07D295/18 ; A61K31/40 ; A61K31/425 ; A61K31/435 ; A61K31/54 ; C07D207/20
摘要:
Drugs for improving cerebral circulation, cerebral metabolism and memory containing as the active ingredient a phenylalkanoylamine derivative or its salt represented by general formula (I) (wherein A represents a 1,3-thiazolin-3-yl group, a 1,2,3,6-tetrahydropyridin-1-yl group, a morpholino group, a thiomorpholin-4-yl group or a 3-pyrrolin-1-yl group, R¹ and R² may be the same or different and each represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a nitro group, an amino group or (α) (wherein R³ and R⁴ each represents a lower alkyl group or, when taken together, they represent a 5- or 6-membered heterocyclic group together with the nitrogen atom), and n represents an integer of 2 to 6) and novel phenylalkanoylamine derivatives among the compounds represented by (I), and a process for their preparation are disclosed. The above drugs are useful for treating sequelae of cerebral hemorrhage, sequelae of cerebral infarction, arterial aclerosis of brain, sequelae of subarachnoidal hemorrhage, sequelae of head trauma, sequelae of cerebral operation, dementia of cerebral vessel origin, Parkinson's disease, Alzheimer's disease, Pick's disease, sequelae of hypoxia, alcoholic cerebral diseases, etc.
信息查询