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    ENTERIC COATED TABLET
    4.
    发明公开
    ENTERIC COATED TABLET 审中-公开
    MAGENSAFTRESISTENTE TABLETTE

    公开(公告)号：EP2959892A1

    公开(公告)日：2015-12-30

    申请号：EP14754975.2

    申请日：2014-02-21

    申请人： Zeria Pharmaceutical Co., Ltd.

    发明人： RYU, Akio ,  OSADA, Miyako

    IPC分类号： A61K9/36 ,  A61K31/606 ,  A61K45/00 ,  A61K47/32 ,  A61K47/38 ,  A61P1/04

    摘要： To provide an enteric coated tablet containing a large amount of medicinal ingredient and having sufficient impact resistance, without forming a thick enteric coating layer.
    The enteric coated tablet contains (A) a core tablet containing a medicinal ingredient and having a weight of 1,000 mg or more; (B) a coating layer containing a water-soluble polymer applied onto the surface of the core tablet; and (C) an enteric coating layer dissolving at pH 7 or higher which is applied onto the surface of the coating layer containing a water-soluble polymer, wherein the sum of the polymer amount of the coating layer (B) and the polymer amount of the coating layer (C) is 10 to 18 mg/cm 2 , the polymer amount of the coating layer (B) is 6 to 12 mg/cm 2 , and the polymer amount of the coating layer (C) is 3 to 6 mg/cm 2 .

    摘要翻译： 提供含有大量药用成分并且具有足够抗冲击性的肠溶衣片剂，而不形成厚的肠溶衣层。 肠溶片包含（A）含有药物成分并且重量为1,000mg以上的核心片剂; （B）涂布在芯片表面上的水溶性聚合物的涂层; 和（C）在pH7以上溶解的肠溶衣层，其涂布在含有水溶性聚合物的被覆层的表面上，其中，涂布层（B）的聚合物量与聚合物的量 涂层（C）为10〜18mg / cm 2，涂层（B）的聚合物的量为6〜12mg / cm 2，涂层（C）的聚合物量为3〜6mg / cm 2。

    METHOD FOR PRODUCING 2-BROMO-4,5-DIALKOXY BENZOIC ACID
    5.
    发明公开
    METHOD FOR PRODUCING 2-BROMO-4,5-DIALKOXY BENZOIC ACID 有权
    VERFAHREN ZUR HERSTELLUNG VON 2-BROM-4,5-DIALKOXY-BENZOESURE

    公开(公告)号：EP2650277A1

    公开(公告)日：2013-10-16

    申请号：EP11847027.7

    申请日：2011-12-06

    申请人： Zeria Pharmaceutical Co., Ltd.

    发明人： NAKAO, Ryu

    IPC分类号： C07C51/363 ,  C07C51/367 ,  C07C65/21 ,  C07B61/00

    CPC分类号： C07C51/363 ,  C07C51/367 ,  C07C65/21

    摘要： Provided is a method for effectively producing a 4,5-dialkoxy-2-hydroxybenzoic acid from an inexpensive raw material.
    A method for producing a 2-bromo-4,5-dialkoxybenzoic acid represented by the following formula (2):
    (wherein each of R 1 and R 2 represents a lower alkyl group), the method including causing a 3,4-dialkoxybenzoic acid represented by the following formula (1):
    (wherein R 1 and R 2 have the same meanings as defined above) to react with bromine in concentrated hydrochloric acid.

    摘要翻译： 提供了从廉价的原料有效地制备4,5-二烷氧基-2-羟基苯甲酸的方法。 由下式（2）表示的2-溴-4,5-二烷氧基苯甲酸的制造方法（其中，R 1和R 2各自表示低级烷基），该方法包括使3,4-二烷氧基苯甲酸 由下式（1）表示的酸（其中R 1和R 2具有与上述相同的含义）与溴在浓盐酸中反应。

    ORALLY ADMINISTRABLE TABLET FOR INTESTINAL LAVAGE
    6.
    发明公开
    ORALLY ADMINISTRABLE TABLET FOR INTESTINAL LAVAGE 有权
    ORAL VERABREICHTE TABLETTE ZUR DARMREINIGUNG

    公开(公告)号：EP2476424A1

    公开(公告)日：2012-07-18

    申请号：EP10811523.9

    申请日：2010-08-27

    申请人： Zeria Pharmaceutical Co., Ltd.

    发明人： NOMURA, Masafumi ,  NISHIYAMA, Tetsuyuki ,  ICHIKAWA, Mari ,  FUKAYA, Kyoko

    IPC分类号： A61K33/42 ,  A61K9/20 ,  A61K31/717 ,  A61P1/10 ,  A61K49/00

    CPC分类号： A61K33/42 ,  A61K9/2054 ,  A61K31/717 ,  A61K45/06 ,  A61K2300/00

    摘要： To provide a peroral tablet for bowel cleansing which leaves no remains in the intestinal tract after bowel cleansing, which exhibits a dissolution property equivalent to that of conventional sodium phosphate-containing tablets including crystalline cellulose, and which is a small-size agent readily taken by a subject.
    The peroral tablet for bowel cleansing containing the following ingredients (A) and (B):
    (A) 80 to 95 mass% of sodium phosphate, and
    (B) (B1) 7 to 11 mass% of hydroxypropyl cellulose which has such a particle size that ≥99% of the particles thereof pass through a mesh having an opening of 350 µm and whose 2-mass% aqueous solution has a viscosity of 2.0 to 10.0 mPa·s,
    (B2) 5 to 13 mass% of hydroxypropyl cellulose which has such a particle size that ≥99% of the particles thereof pass through a mesh having an opening of 150 µm and whose 2-mass% aqueous solution has a viscosity of 3.0 to 5.9 mPa·s, or
    (B3) 7 to 11 mass% of hydroxypropyl cellulose which has such a particle size that ≥99% of the particles thereof pass through a mesh having an opening of 150 µm and whose 2-mass% aqueous solution has a viscosity of 6.0 to 4,000 mPa·s, and
    having a water-insoluble ingredient content of 5 mass% or less.

    摘要翻译： 提供肠道清洁的口服片剂，其在肠清洗后没有留下肠道残留物，其显示出与包含结晶纤维素的常规含磷酸钠片剂相当的溶解性能，并且其是容易被 课程。 含有以下成分（A）和（B）的肠溶清洁口服片剂：（A）80〜95质量％的磷酸钠，（B）（B1）7〜11质量％的具有这样的粒子的羟丙基纤维素 粒径为99％的颗粒通过开孔为350μm的网，其2质量％的水溶液的粘度为2.0〜10.0mPa·s，（B2）为5〜13质量％的羟丙基纤维素 其粒径为99％以上的颗粒通过开孔为150μm的网，其2质量％的水溶液的粘度为3.0〜5.9mPa·s，或（B3）7〜 粒径为99％以下的羟丙基纤维素11质量％通过开孔为150μm的网眼，其2质量％的水溶液的粘度为6.0〜4000mPa·s， 并且具有5质量％以下的水不溶性成分含量。

    ANTITUMOR AGENT
    10.
    发明授权
    ANTITUMOR AGENT 有权
    抗癌剂

    公开(公告)号：EP1839662B1

    公开(公告)日：2010-03-24

    申请号：EP06711726.7

    申请日：2006-01-16

    申请人： ZERIA PHARMACEUTICAL CO., LTD.

    发明人： YOSHINAGA, Koji ,  KAWASAKI, Daisuke ,  EMORI, Yutaka

    IPC分类号： A61K31/551 ,  A61K45/00 ,  A61P35/00 ,  A61P35/02 ,  C07D243/12

    CPC分类号： A61K31/551 ,  A61K9/0053 ,  A61K31/513 ,  A61K31/7068 ,  A61K45/06 ,  C07D243/12 ,  A61K2300/00

    摘要： To provide a pharmaceutical agent or an antitumor agent useful for the treatment and/or prevention of gastrointestinal cancer, leukemia, pituitary tumor, small cell lung cancer, thyroid cancer, and neuroastrocytoma. The antitumor agent containing, as an active ingredient, a 1,5-benzodiazepine derivative represented by the following formula (1) : (wherein R 1 represents a C 1-6 alkyl group; R 2 represents a phenyl group or a cyclohexyl group; and Y represents a single bond or a C 1-4 alkylene group) or a pharmaceutically acceptable salt thereof.

    摘要翻译： 一种抗肿瘤药物，一种用于治疗或预防消化系统癌症，白血病，垂体瘤，小细胞肺癌，甲状腺癌和神经星形细胞瘤的药物。 （1）表示的1,5-苯并二氮杂衍生物作为有效成分：（式中，R1表示C1-6烷基，R2表示苯基或环己基，Y表示单键或C1-4 亚烷基）或其药学上可接受的盐。