发明公开
- 专利标题： Novel platinum complexes
- 专利标题（中）： Platin Komplexe。
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申请号： EP91106490.5申请日： 1991-04-23
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公开(公告)号： EP0454042A2公开(公告)日： 1991-10-30
- 发明人: Kogawa, Osamu , Iwata, Kenji , Ekimoto, Hisao , Ishii, Tadashi , Takada, Kimihiko
- 申请人： Nippon Kayaku Kabushiki Kaisha
- 申请人地址： 11-2, Fujimi-cho 1 chome Chiyoda-ku Tokyo JP
- 专利权人： Nippon Kayaku Kabushiki Kaisha
- 当前专利权人： Nippon Kayaku Kabushiki Kaisha
- 当前专利权人地址： 11-2, Fujimi-cho 1 chome Chiyoda-ku Tokyo JP
- 代理机构： Türk, Gille, Hrabal, Leifert
- 优先权： JP107341/90 19900425
- 主分类号： C07F15/00
- IPC分类号： C07F15/00 ; A61K31/28
摘要：
A platinum (II) complex represented by the general formula:
[wherein A's are each ammonia or two A's jointly represent 1,2-diaminocyclohexane, 1-amino-1-aminomethylcyclohexane or 1,4-diamino-2-methylbutane; and B's may be same or different and represent
(wherein m is 0, 1 or 2; n is 0 or 1; R₁ is a C₃-C₆ alkyl group substituted with one or two hydroxyl groups) or two B's jointly represent
(wherein R₂ is a C₂-C₅ alkyl group substituted with one hydroxyl group)].
These platinum (II) complexes have high potencies for use as an antitumor agent.
[wherein A's are each ammonia or two A's jointly represent 1,2-diaminocyclohexane, 1-amino-1-aminomethylcyclohexane or 1,4-diamino-2-methylbutane; and B's may be same or different and represent
(wherein m is 0, 1 or 2; n is 0 or 1; R₁ is a C₃-C₆ alkyl group substituted with one or two hydroxyl groups) or two B's jointly represent
(wherein R₂ is a C₂-C₅ alkyl group substituted with one hydroxyl group)].
These platinum (II) complexes have high potencies for use as an antitumor agent.
公开/授权文献
- EP0454042A3 Novel platinum complexes 公开/授权日：1993-02-24
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