公开(公告)号：EP0454042A2

公开(公告)日：1991-10-30

申请号：EP91106490.5

申请日：1991-04-23

申请人： Nippon Kayaku Kabushiki Kaisha

发明人： Kogawa, Osamu ,  Iwata, Kenji ,  Ekimoto, Hisao ,  Ishii, Tadashi ,  Takada, Kimihiko

IPC分类号： C07F15/00 ,  A61K31/28

CPC分类号： C07F15/0093

摘要： A platinum (II) complex represented by the general formula:

[wherein A's are each ammonia or two A's jointly represent 1,2-diaminocyclohexane, 1-amino-1-aminomethylcyclohexane or 1,4-diamino-2-methylbutane; and B's may be same or different and represent

(wherein m is 0, 1 or 2; n is 0 or 1; R₁ is a C₃-C₆ alkyl group substituted with one or two hydroxyl groups) or two B's jointly represent

(wherein R₂ is a C₂-C₅ alkyl group substituted with one hydroxyl group)].
These platinum (II) complexes have high potencies for use as an antitumor agent.

摘要翻译： 由以下通式表示的铂（II）络合物： [其中A各自为氨或两个A共同表示1,2-二氨基环己烷，1-氨基-1-氨基甲基环己烷或1,4-二氨基-2-甲基丁烷; 并且B可以相同或不同，表示（其中m为0,1或2; n为0或1; R 1为被一个或两个羟基取代的C 3 -C 6烷基）或两个B共同表示< CHEM>（其中R2是被一个羟基取代的C2-C5烷基）]。 这些铂（II）配合物具有高效力用作抗肿瘤剂。

公开(公告)号：EP0454042A3

公开(公告)日：1993-02-24

申请号：EP91106490.5

申请日：1991-04-23

申请人： Nippon Kayaku Kabushiki Kaisha

发明人： Kogawa, Osamu ,  Iwata, Kenji ,  Ekimoto, Hisao ,  Ishii, Tadashi ,  Takada, Kimihiko

IPC分类号： C07F15/00 ,  A61K31/28

CPC分类号： C07F15/0093

摘要： A platinum (II) complex represented by the general formula:

[wherein A's are each ammonia or two A's jointly represent 1,2-diaminocyclohexane, 1-amino-1-aminomethylcyclohexane or 1,4-diamino-2-methylbutane; and B's may be same or different and represent

(wherein m is 0, 1 or 2; n is 0 or 1; R₁ is a C₃-C₆ alkyl group substituted with one or two hydroxyl groups) or two B's jointly represent

(wherein R₂ is a C₂-C₅ alkyl group substituted with one hydroxyl group)]. These platinum (II) complexes have high potencies for use as an antitumor agent.