发明公开
- 专利标题： Benzimidazolinone derivatives
- 专利标题（中）： 苯并咪唑啉酮衍生物
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申请号： EP91303264.5申请日： 1991-04-12
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公开(公告)号： EP0454330A1公开(公告)日： 1991-10-30
- 发明人: Hara, Hiromu , Maruyama, Tatsuya , Saito, Munetoshi , Takeuchi, Makoto , Mase, Toshiyasu
- 申请人： YAMANOUCHI PHARMACEUTICAL CO. LTD.
- 申请人地址： No. 3-11 Nihonbashi-Honcho, 2-chome Chuo-ku Tokyo JP
- 专利权人： YAMANOUCHI PHARMACEUTICAL CO. LTD.
- 当前专利权人： YAMANOUCHI PHARMACEUTICAL CO. LTD.
- 当前专利权人地址： No. 3-11 Nihonbashi-Honcho, 2-chome Chuo-ku Tokyo JP
- 代理机构： Geering, Keith Edwin
- 优先权： JP98455/90 19900413; JP285493/90 19901023
- 主分类号： C07D235/26
- IPC分类号： C07D235/26 ; A61K31/415 ; C07D403/04
摘要：
Benzimidazolinone derivatives of the general formula (I):
wherein R 1 , R 2 and R 3 , which may be the same or different, each is a hydrogen or halogen atom or a lower alkyl, halo-lower alkyl, hydroxy-lower alkyl, hydroxyl, lower alkoxy, aryloxy, acyl, cyano, carboxyl, a lower alkoxycarbonyl, carbamoyl, nitro or nitrogen-containing 5- or 6-membered heterocyclic group; A is an ethylene group which may optionally have at least one branch ; R 4 and R 5 , which may be the same or different, each is a lower alkyl group or R 4 and R 5 , together with the adjacent nitrogen atom, represent a pyrrolidinyl, piperidino or a morpholino group provided that when
is a piperidino or diethylamino group, at least one of R 1 , R 2 and R 3 is other than a hydrogen atom, or pharmaceutically acceptable salts thereof, methods of producing the same and pharmaceutical compositions containing the same are disclosed. Pharmacologically, the above compounds (I) have pulmonary surfactant secretion promoting activity.
wherein R 1 , R 2 and R 3 , which may be the same or different, each is a hydrogen or halogen atom or a lower alkyl, halo-lower alkyl, hydroxy-lower alkyl, hydroxyl, lower alkoxy, aryloxy, acyl, cyano, carboxyl, a lower alkoxycarbonyl, carbamoyl, nitro or nitrogen-containing 5- or 6-membered heterocyclic group; A is an ethylene group which may optionally have at least one branch ; R 4 and R 5 , which may be the same or different, each is a lower alkyl group or R 4 and R 5 , together with the adjacent nitrogen atom, represent a pyrrolidinyl, piperidino or a morpholino group provided that when
is a piperidino or diethylamino group, at least one of R 1 , R 2 and R 3 is other than a hydrogen atom, or pharmaceutically acceptable salts thereof, methods of producing the same and pharmaceutical compositions containing the same are disclosed. Pharmacologically, the above compounds (I) have pulmonary surfactant secretion promoting activity.
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