发明授权
- 专利标题： IL-1 BIOLOGICAL ACTIVITY INHIBITORS
- 专利标题（中）： IL-1，它的生物活性抑制
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申请号： EP90904008.1申请日： 1990-02-23
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公开(公告)号： EP0460052B1公开(公告)日： 1998-04-15
- 发明人: GEHRKE, Lee , AURON, Philip, E. , ROSENWASSER, Lanny
- 申请人： NEW ENGLAND MEDICAL CENTER , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- 申请人地址： 750 Washington Street Boston, MA 02111 US
- 专利权人： NEW ENGLAND MEDICAL CENTER,MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- 当前专利权人： NEW ENGLAND MEDICAL CENTER,MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- 当前专利权人地址： 750 Washington Street Boston, MA 02111 US
- 代理机构： Perry, Robert Edward
- 优先权： US316278 19890227
- 国际公布： WO9010068 19900907
- 主分类号： C12N15/25
- IPC分类号： C12N15/25 ; C12P21/02
摘要：
Disclosed are novel muteins of IL-1 compounds which can be used to regulate excess IL-1 produced in various diseases in humans and animals. The IL-1 muteins can be prepared by site-directed mutagenesis whereby a positively charged residue is replaced with a negatively charged or neutral residue at a designated position in the molecule. The resulting IL-1 muteins have reduced biological activity but retain receptor binding affinity.
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