发明公开
- 专利标题： Chimeric plasminogen activators
- 专利标题（中）： ChimärePlasminogenaktivatoren。
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申请号： EP91201447.9申请日： 1991-06-11
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公开(公告)号： EP0462651A1公开(公告)日： 1991-12-27
- 发明人: Collen, Désiré J. , Lijnen, Roger H. , Nelles, Lucien G.R. , Stassen, Jean-Marie E.I.
- 申请人： Leuven Research & Development V.Z.W.
- 申请人地址： Benedenstraat 59A Groot Begijnhof B-3000 Leuven BE
- 专利权人： Leuven Research & Development V.Z.W.
- 当前专利权人： Leuven Research & Development V.Z.W.
- 当前专利权人地址： Benedenstraat 59A Groot Begijnhof B-3000 Leuven BE
- 代理机构： Bruin, Cornelis Willem
- 优先权： US538458 19900615
- 主分类号： C12N15/58
- IPC分类号： C12N15/58 ; C12N9/72 ; C12N5/10 ; A61K37/54
摘要：
Chimeric plasminogen activators comprising at least the enzymatic region of urokinase-type plasminogen activator in combination with polypeptide material from another source, will sometimes show improved thrombolytic potency in vivo. The other polypeptide material is preferably a fragment, without substantial fibrin-affinity from the non-enzymatic portion of tissue-type plasminogen activator. The most preferred product is a chimeric molecule comprising aminoacids 1 to 3 and 87 to 274 of tissue-type plasminogen activator fused to aminoacids 138 to 411 of urokinase-type plasminogen activator. These products may occur in single-chain or two-chain form and may be used in pharmaceutical compositions for the treatment of thromboembolic diseases.
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