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公开(公告)号：EP1503213A2
公开(公告)日：2005-02-02
申请号：EP04077760.9
申请日：1999-08-31
CPC分类号： G01N33/721 , G01N33/6893 , G01N33/92 , G01N2800/32 , G01N2800/323 , G01N2800/324 , Y10S435/967 , Y10S435/973 , Y10S436/809 , Y10S436/819 , Y10T436/104165 , Y10T436/105831
摘要： A method for detecting coronary artery disease for a human patient from the general population and staging the disease, if detected; the method comprising performing the step of testing a sample from the patient for a clinically significant presence of a second marker comprising a malondialdehyde-modified atherogenic protein that is recognized by a scavenger receptor on a macrophage; and performing at least one of the following steps of either testing a sample from the patient for a clinically significant presence of a first marker comprising an oxidized atherogenic protein that is no longer recognized by a low density lipoprotein receptor but is recognized by a scavenger receptor on a macrophage; or testing a sample from the patient for a clinically significant presence of a heart protein; wherein the results from the first step and at least one of the other steps indicates whether the level of the marker in the sample from the individual is clinically significant.
摘要翻译： 一种用于从普通人群中检测人类患者的冠状动脉疾病并检测该疾病的方法，如果检测到的话; 所述方法包括进行测试来自患者的样品以临床上显着存在第二标记的步骤，所述第二标记包含被巨噬细胞上的清道夫受体识别的丙二醛修饰的致动脉粥样化蛋白; 并且执行以下步骤中的至少一个：对来自患者的样品测试临床上显着存在的第一标记物，所述第一标记物包含不再被低密度脂蛋白受体识别但被清道夫受体识别的氧化的致动脉粥样硬化蛋白质 巨噬细胞; 或测试来自患者的样品临床上显着存在的心脏蛋白质; 其中来自第一步骤的结果和至少一个其他步骤指示来自个体的样品中标志物的水平是否在临床上显着。
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公开(公告)号：EP1110092B1
公开(公告)日：2004-11-03
申请号：EP99944731.1
申请日：1999-08-31
CPC分类号： G01N33/721 , G01N33/6893 , G01N33/92 , G01N2800/32 , G01N2800/323 , G01N2800/324 , Y10S435/967 , Y10S435/973 , Y10S436/809 , Y10S436/819 , Y10T436/104165 , Y10T436/105831
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3.发明公开Hybrid plasminogen activators with improved thrombolytic properties and drugs comprising these plasminogen activators 失效混合型纤溶酶原激活剂血小板凝集素Eigenschaften und diese Plasminogenaktivatoren enthaltende Medikamente。
公开(公告)号：EP0275606A1
公开(公告)日：1988-07-27
申请号：EP87202610.9
申请日：1987-12-22
发明人： Collen, Désiré José , Holmes, William Evans , Nelles, Lucien Georges Raymond , Lijnen, Henri Roger
CPC分类号： C12N9/6456 , C07K14/53 , C07K2319/00 , C12N9/64
摘要： The invention relates to plasminogen activators obtained by expression of fused cDNA encoding fragments of human tissue-type plasminogen activator (t-PA) and of human urokinase-type plasminogen activator (u-PA), by combining the fibrin-affinity of t-PA with the fibrin-specificity of u-PA in the single chain form (scu-PA) and,or with the enzymatic activity of u-PA having the two-chain form (tcu-PA). It is preferably a hybrid molecule obtained by fusion of at least a region part of the NHz-terminal region of t-PA to at least a part region of the COOH-terminal region of scu-PA, most preferably the NH 2 -terminal amino acids 1 to 263 of t-PA, fused to the COOH-terminal amino acids 144 to 411 of scu-PA.
The invention relates further to a recombinant DNA molecule which yields said hybrid plasminogen activators; the respective mammalian expression vector containing said DNA sequence; a transfected mammalian cell line which comprises said recombinant DNA molecule; and to the method for the preparation of plasminogen activators.摘要翻译： 本发明涉及通过表达编码人组织型纤溶酶原激活物（t-PA）和人尿激酶型纤溶酶原激活物（u-PA）片段的融合cDNA获得的纤溶酶原激活物，通过结合t-PA的纤维蛋白亲和力 其中u-PA在单链形式（scu-PA）中的纤维蛋白特异性和/或具有双链形式（tcu-PA）的u-PA的酶活性。 优选通过将t-PA的NH 2末端区域的至少一部分区域与scu-PA的COOH末端区域的至少一部分区域融合而得到的杂合分子，最优选NH 2末端氨基酸 1至263的t-PA，与scu-PA的COOH末端氨基酸144至411融合。 本发明还涉及产生所述杂合纤溶酶原激活物的重组DNA分子; 含有所述DNA序列的各个哺乳动物表达载体; 包含所述重组DNA分子的转染的哺乳动物细胞系; 以及制备纤溶酶原激活物的方法。
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4.发明公开Pharmaceutical composition having thrombolytic activity 失效药剂师Zusammensetzung mit thrombolytischer Wirkung。
公开(公告)号：EP0223192A1
公开(公告)日：1987-05-27
申请号：EP86115665.1
申请日：1986-11-11
发明人： Collen, Désiré José
IPC分类号： A61K37/54
CPC分类号： A61K38/49
摘要： Plasminogen activators of the tissue-type and plasminogen activators of the urokinase-type appear to have a synergistic action in vivo when administered together as thrombolytic agents. This can be used in pharmaceutical compositions and in methods for the preparation and use thereof.
摘要翻译： 尿激酶型组织型和纤溶酶原激活剂的纤溶酶原激活剂似乎在一起作为溶栓剂一起施用时在体内具有协同作用。 这可以用于药物组合物和制备和使用方法中。
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5.发明授权Method and device for assessing and checking the circumferential shape of an object 失效用于评估和检查对象的圆形形状的方法和装置
公开(公告)号：EP0006663B1
公开(公告)日：1982-05-12
申请号：EP79200321.2
申请日：1979-06-20
CPC分类号： G01B11/2433 , G01B11/022
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公开(公告)号：EP0462651A1
公开(公告)日：1991-12-27
申请号：EP91201447.9
申请日：1991-06-11
CPC分类号： C12N9/6456 , A61K38/00 , C07K2319/00
摘要： Chimeric plasminogen activators comprising at least the enzymatic region of urokinase-type plasminogen activator in combination with polypeptide material from another source, will sometimes show improved thrombolytic potency in vivo. The other polypeptide material is preferably a fragment, without substantial fibrin-affinity from the non-enzymatic portion of tissue-type plasminogen activator. The most preferred product is a chimeric molecule comprising aminoacids 1 to 3 and 87 to 274 of tissue-type plasminogen activator fused to aminoacids 138 to 411 of urokinase-type plasminogen activator. These products may occur in single-chain or two-chain form and may be used in pharmaceutical compositions for the treatment of thromboembolic diseases.
摘要翻译： 包含至少尿激酶型纤溶酶原激活物的酶区域与来自另一来源的多肽材料组合的嵌合型纤溶酶原激活剂有时会在体内显示改善的溶栓效力。 另一种多肽材料优选是片段，与组织型纤溶酶原激活物的非酶部分没有实质的纤维蛋白亲和力。 最优选的产物是包含与尿激酶型纤溶酶原激活剂的氨基酸138至411融合的组织型纤溶酶原激活物的氨基酸1至3和87至274的嵌合分子。 这些产物可以单链或双链形式发生，并且可以用于治疗血栓栓塞性疾病的药物组合物中。
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公开(公告)号：EP0098646A3
公开(公告)日：1985-05-22
申请号：EP83200955
申请日：1983-06-28
发明人： Maertens, Jaak
IPC分类号： G05D23/02
摘要： A device delivering a movement in response to cold, as an imput signal, generated by the expansion of a cryogenic liquid such as freon, butane or propane. The device comprises a shape memory alloy element located in the stream of the escaping expanded gas and changing from a warm to a cold form when struck by such gas stream. Can for instance be used for commanding a valve or for detecting the level of a cryogenic liquid.
摘要翻译： 通过膨胀低温液体如氟利昂，丁烷或丙烷而产生的作为输入信号的冷响应的装置。 该装置包括位于逸出的膨胀气体流中的形状记忆合金元件，当被这种气流撞击时，形状记忆合金元件从温热变为冷形式。 例如可以用于指示阀门或用于检测低温液体的液位。
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公开(公告)号：EP0098646A2
公开(公告)日：1984-01-18
申请号：EP83200955.9
申请日：1983-06-28
发明人： Maertens, Jaak
IPC分类号： G05D23/02
摘要： A device delivering a movement in response to cold, as an imput signal, generated by the expansion of a cryogenic liquid such as freon, butane or propane. The device comprises a shape memory alloy element located in the stream of the escaping expanded gas and changing from a warm to a cold form when struck by such gas stream. Can for instance be used for commanding a valve or for detecting the level of a cryogenic liquid.
摘要翻译： 通过膨胀低温液体如氟利昂，丁烷或丙烷而产生的作为输入信号的冷响应的装置。 该装置包括位于逸出的膨胀气体流中的形状记忆合金元件，当被这种气流撞击时，形状记忆合金元件从温热变为冷形式。 例如可以用于指示阀门或用于检测低温液体的液位。
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公开(公告)号：EP0041755A1
公开(公告)日：1981-12-16
申请号：EP81200599.9
申请日：1981-06-03
摘要： Warning device to signal the passing of a predetermined temperature level in the environment thereof, comprising heat-conducting fixing means and a cylindrical first tube (9) enclosing a spring element with shape memory effect (11) and a telescoping second tube (12) which can be displaced by said spring element acting in its extended position as a signal.
摘要翻译： 警告装置在其环境中表示通过预定温度水平，包括导热固定装置和包围具有形状记忆效应（11）的弹簧元件和伸缩第二管（12）的圆柱形第一管（9） 可以被作为信号作用在其伸出位置的所述弹簧元件移位。
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