发明公开
EP0464009A3 Oligopeptide derivatives of ipoxantine endowed with immunomodulating activity and pharmaceutical compositions containing same
失效
含有免疫调节活性的IPOXANTINE的寡肽衍生物和含有其的药物组合物
- 专利标题： Oligopeptide derivatives of ipoxantine endowed with immunomodulating activity and pharmaceutical compositions containing same
- 专利标题（中）： 含有免疫调节活性的IPOXANTINE的寡肽衍生物和含有其的药物组合物
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申请号： EP91830284.5申请日： 1991-06-26
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公开(公告)号： EP0464009A3公开(公告)日： 1992-06-17
- 发明人: Marzi, Mauro , Foresta, Piero , Minetti, Patrizia , Tinti, Maria Ornella
- 申请人： Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
- 申请人地址： Viale Shakespeare, 47 I-00144 Roma IT
- 专利权人： Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
- 当前专利权人： Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
- 当前专利权人地址： Viale Shakespeare, 47 I-00144 Roma IT
- 代理机构： Cavattoni, Fabio
- 优先权： IT4810290 19900628
- 主分类号： C07K5/00
- IPC分类号： C07K5/00 ; A61K37/02
摘要：
Ipoxantine derivatives of general formula (I):
both as racemate and chiral forms and the salts thereof with pharmacologically acceptable cations, wherein n is an integer comprised between 2 and 6, and A is the residue of a dipeptide, tripeptide, tetrapeptide and pentapeptide selected, respectively, from the groups consisting of:
(a) glycyl-aspartate, alanyl-glycine, glycyl-glycine, aspartyl-arginine, leucyl-arginine; (b) arginyl-lysyl-aspartate, aspartyl-lysyl-arginine, lysyl-prolyl-arginine, prolyl-prolyl-arginine, lysyl-histidyl-glycinamide, prolyl-phenilalanyl-arginine, phenylalanyl-prolyl-arginine; (c) arginyl-lysyl-aspartyl-valine, valyl-aspartyl-lysyl-arginine, threonylvalyl-leucyl-histidyne; and (d) arginyl-lysyl-aspartyl-valyl-tyrosine; are endowed with immunomodulating activity and can be formulated in orally or parenterally administrable pharmaceutical compositions.
both as racemate and chiral forms and the salts thereof with pharmacologically acceptable cations, wherein n is an integer comprised between 2 and 6, and A is the residue of a dipeptide, tripeptide, tetrapeptide and pentapeptide selected, respectively, from the groups consisting of:
(a) glycyl-aspartate, alanyl-glycine, glycyl-glycine, aspartyl-arginine, leucyl-arginine; (b) arginyl-lysyl-aspartate, aspartyl-lysyl-arginine, lysyl-prolyl-arginine, prolyl-prolyl-arginine, lysyl-histidyl-glycinamide, prolyl-phenilalanyl-arginine, phenylalanyl-prolyl-arginine; (c) arginyl-lysyl-aspartyl-valine, valyl-aspartyl-lysyl-arginine, threonylvalyl-leucyl-histidyne; and (d) arginyl-lysyl-aspartyl-valyl-tyrosine; are endowed with immunomodulating activity and can be formulated in orally or parenterally administrable pharmaceutical compositions.
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