发明公开
EP0465716A1 Optically active thiazetoquino-line-3-carboxylic acid compound, method for preparation thereof, and a pharmaceutical composition comprising the same
失效
光学活性Thiazetochinolin -3-羧酸化合物，它们的制备方法和含有药物组合物。
- 专利标题： Optically active thiazetoquino-line-3-carboxylic acid compound, method for preparation thereof, and a pharmaceutical composition comprising the same
- 专利标题（中）： 光学活性Thiazetochinolin -3-羧酸化合物，它们的制备方法和含有药物组合物。
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申请号： EP90119802.8申请日： 1990-10-16
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公开(公告)号： EP0465716A1公开(公告)日： 1992-01-15
- 发明人: Ito, Yasuo , Kato, Hideo , Koshinaka, Eiichi , Ogawa, Nobuo , Yagi, Noriyuki , Yoshida, Toshihiko , Suzuki, Tomio
- 申请人： HOKURIKU PHARMACEUTICAL CO., LTD.
- 申请人地址： 1-Chome, 3-14, Tatekawacho, Katsuyama-shi Fukui-ken 911 JP
- 专利权人： HOKURIKU PHARMACEUTICAL CO., LTD.
- 当前专利权人： HOKURIKU PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： 1-Chome, 3-14, Tatekawacho, Katsuyama-shi Fukui-ken 911 JP
- 代理机构： Werner, Hans-Karsten, Dr.Dipl.-Chem.
- 优先权： JP180663/90 19900710
- 主分类号： C07D513/04
- IPC分类号： C07D513/04 ; A61K31/435
摘要：
An optically active thiazetoquinoline-3-carboxylic acid compound represented by the following formula (I):
wherein R¹ is a hydrogen atom or a lower alkyl group; R² is a fluorine atom or a chlorine atom; R³ is a hydrogen atom, a lower alkanoyl group, a halogenated lower alkanoyl, or the residue of carboxylic acid ester; and C * represents an asymmetric carbon atom of S- or R-configuration, a pharmacologically acceptable salt thereof, and a method for preparing the compound are disclosed. Also disclosed are antibacterial agent, antineoplastic agent, and anti-AIDS virus agent comprising the same, a pharmaceutical composition for the treatment of bacterial infectious disease, tumor, and AIDS comprising an effective amount of the same.
wherein R¹ is a hydrogen atom or a lower alkyl group; R² is a fluorine atom or a chlorine atom; R³ is a hydrogen atom, a lower alkanoyl group, a halogenated lower alkanoyl, or the residue of carboxylic acid ester; and C * represents an asymmetric carbon atom of S- or R-configuration, a pharmacologically acceptable salt thereof, and a method for preparing the compound are disclosed. Also disclosed are antibacterial agent, antineoplastic agent, and anti-AIDS virus agent comprising the same, a pharmaceutical composition for the treatment of bacterial infectious disease, tumor, and AIDS comprising an effective amount of the same.
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