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44 条记录 (耗时 0.016 秒)

    Amphoteric tricyclic compounds as antihistaminic and antiallergic agents
    1.
    发明公开
    Amphoteric tricyclic compounds as antihistaminic and antiallergic agents 失效
    Amphotere tricyclische Verbindungen als antihistaminische und antiallergische Mittel。

    公开(公告)号：EP0556813A1

    公开(公告)日：1993-08-25

    申请号：EP93102518.3

    申请日：1993-02-18

    申请人： HOKURIKU PHARMACEUTICAL CO., LTD.

    发明人： Ito, Yasuo ,  Kato, Hideo ,  Yasuda, Shingo ,  Kado, Noriyuki ,  Iwasaki, Nobuhiko ,  Nishino, Hiroyuki ,  Takeshita, Makoto

    IPC分类号： C07D491/044 ,  C07D491/052 ,  A61K31/445

    CPC分类号： C07D491/04

    摘要： Novel amphoteric tricyclic compound represented by the following formula:

    wherein R¹ represents a hydrogen atom or a halogen atom; X represents -O-, -CH₂O-, or -OCH₂-; and Y represents a C₂-C₅ alkylene group which may optionally be substituted with a lower alkyl group, and a pharmacologically acceptable salt thereof are disclosed. Also disclosed are a method for preparing the same, a pharmaceutical composition comprising the same useful as an antiallergic agent and an agent for bronchial asthma, and a method for treatment of an allergic disease or bronchial asthma comprising the step of administering the same.

    摘要翻译： 由下式表示的新型两性三环化合物：其中R 1表示氢原子或卤素原子的 X表示-O-，-CH 2 O-或-OCH 2 - ; 并且Y表示可以任选被低级烷基取代的C 2 -C 5亚烷基及其药理学上可接受的盐。 还公开了其制备方法，包含与抗过敏剂和支气管哮喘药有关的药物组合物的药物组合物，以及治疗过敏性疾病或支气管哮喘的方法，其包括施用该过敏性疾病或支气管哮喘的步骤。

    Piperidine compounds, method for preparation thereof, and a pharamceutical composition comprising the same
    2.
    发明公开
    Piperidine compounds, method for preparation thereof, and a pharamceutical composition comprising the same 失效
    哌啶类化合物，它们的制备方法和药物组合物。

    公开(公告)号：EP0451772A1

    公开(公告)日：1991-10-16

    申请号：EP91105567.1

    申请日：1991-04-09

    申请人： HOKURIKU PHARMACEUTICAL CO., LTD.

    发明人： Ito, Yasuo ,  Kato, Hideo ,  Koshinaka, Eiichi ,  Ogawa, Nobuo ,  Nishino, Hiroyuki ,  Sakaguchi, Jun

    IPC分类号： C07D409/04 ,  A61K31/445

    CPC分类号： C07D409/04

    摘要： Novel piperidine compounds represented by the following formula (I):

    wherein Y represents an alkylene group having 1 to 7 carbon atoms; A is a group represented by formula I-a or formula I-b:

    wherein X represents -CH₂-S- or -S-; and R represents a hydrogen atom or a lower alkyl group with a proviso that A is a group represented by formula I-a, or R represents a hydrogen atom with a proviso that A is a group represented by formula I-b and pharmacologically acceptable salts thereof are disclosed. Also disclosed are a method for preparing the same; a pharmaceutical composition comprising the same; an antiallergic agent and an agent for bronchial asthma comprising the same; and a method for treatment of an allergic disease or bronchial asthma comprising the step of administering the same.

    摘要翻译： 由下式（I）代表的新的哌啶化合物：具有1至7个碳原子的亚烷基团的worinÿdarstellt; A是由式I-a或式表示的基团I-B： worin X darstellt -CH 2 -S-或-S-; 和R darstellt氢原子或附带条件的低级烷基做A是由式表示的基团I-A，或R darstellt氢原子附带条件没有A是由式I-b和药理学上可接受的其盐盘游离缺失表示的基团。 所以游离缺失盘是其制备方法; 一种药物组合物是相同的; 抗过敏剂和用于支气管哮喘，其包括相同的试剂; 以及用于治疗过敏性疾病的或支气管哮喘的方法，包括给予相同的步骤。

    A polycyclic compound, method for preparing the same, and pharmaceutical composition comprising the same
    3.
    发明公开
    A polycyclic compound, method for preparing the same, and pharmaceutical composition comprising the same 失效
    多环化合物，它们的制备方法和含有它们的药物组合物。

    公开(公告)号：EP0447857A1

    公开(公告)日：1991-09-25

    申请号：EP91103059.1

    申请日：1991-03-01

    申请人： HOKURIKU PHARMACEUTICAL CO., LTD.

    发明人： Sawanishi, Hiroyuki ,  Ito, Yasuo ,  Kato, Hideo ,  Koshinaka, Eiichi ,  Ogawa, Nobuo ,  Morikawa, Kouji

    IPC分类号： C07D267/20 ,  C07D281/16 ,  C07D223/20 ,  C07D487/04 ,  A61K31/55

    CPC分类号： C07D487/04 ,  C07D223/20 ,  C07D267/20 ,  C07D281/16

    摘要： Novel polycyclic compounds represented by the following formula: A - (CH₂) n - COOR¹, wherein R¹ represents a hydrogen atom or a lower alkyl group; n represents an integer of from 0 to 5; and A is a group represented by the following formula:

    wherein X represents a hydrogen atom or a halogen atom; and Y represents a methylene group, an oxygen atom, or a sulfur atom, or A is a group represented by the following formula:

    and pharmacologically acceptable salts thereof are disclosed. Also disclosed are a method for preparing the same, a pharmaceutical composition comprising the same, an antiallergic agent and an agent for bronchial asthma comprising the same, and a method for treatment of an allergic disease or bronchial asthma comprising the step of administering the same.

    摘要翻译： 由下式表示的新颖的多环化合物：A - （CH 2）N - COOR <1>，worin - [R <1>表示一个氢原子或一个低级烷基; Ñdarstellt从0至5的整数; 而且A是由下式表示的基团： worin X darstellt氢原子或卤原子; 和Y darstellt亚甲基氧原子，或硫原子，或A是由下式表示的基团：和它们的游离缺失盘药理学上可接受的盐。 所以游离缺失盘可用于制备其的方法，药物组合物包含相同的抗过敏剂和用于治疗支气管哮喘，其包括相同的药剂，和用于治疗过敏性疾病的或支气管哮喘的方法，包括给予相同的步骤。

    Optically active benzyl alcohol compound and pharmaceutical composition
    4.
    发明公开
    Optically active benzyl alcohol compound and pharmaceutical composition 失效
    光活性苯甲醇醇化合物及其用途

    公开(公告)号：EP0420120A3

    公开(公告)日：1991-09-11

    申请号：EP90118338.4

    申请日：1990-09-25

    申请人： HOKURIKU PHARMACEUTICAL CO., LTD.

    发明人： Ito, Yasuo ,  Kato, Hideo ,  Koshinaka, Eiichi ,  Kurata, Sakae ,  Morikawa, Koji

    IPC分类号： C07C215/60 ,  A61K31/135

    CPC分类号： C07C215/60

    摘要： A levo-rotatory enantiomer of benzyl alcohol compound represented by the following formula (I):
    wherein . C represents an asymmetric carbon atom; a pharmacologically acceptable salt of the compound; and a method for preparing the enantiomer is disclosed. Also disclosed are methods for ralaxing uterine smooth muscle and bladder smooth muscle comprising administering the levo-rotatory enantiomer. Further disclosed is a pharmaceutical composition for the treatment of premature labor or incontinence of urine comprising an effective amount of the levo-rotatory enantiomer together with a pharmaceutically acceptable carrier or coating. Lastly disclosed are methods for the treatment of premature labor or incontinence of urine comprising the steps of determining that a mammal has one of these illnesses and administering the levo-rotatory enantiomer to the mammal.

    Piperidine derivative, method for preparation thereof, and a pharmaceutical composition comprising the same
    5.
    发明公开
    Piperidine derivative, method for preparation thereof, and a pharmaceutical composition comprising the same 失效
    的哌啶衍生物，处理其制备以及含有该药物组合物。

    公开(公告)号：EP0399414A1

    公开(公告)日：1990-11-28

    申请号：EP90109534.9

    申请日：1990-05-19

    申请人： HOKURIKU PHARMACEUTICAL CO., LTD.

    发明人： Itoh, Yasuo ,  Kato, Hideo ,  Koshinaka, Eiichi ,  Ogawa, Nobuo ,  Nishino, Hiroyuki ,  Sakaguchi, Jun

    IPC分类号： C07D211/46 ,  C07D211/54 ,  A61K31/445

    CPC分类号： C07D211/54 ,  C07D211/46

    摘要： A piperidine derivative represented by the following general formula (I):
    wherein R₁ and R₂ are the same or different and each independently represents a hydrogen atom, a halogen atom, a lower alkyl group, or a lower alkoxy group; R₃ represents a hydrogen atom or a lower alkyl group; X represents an oxygen atom or a sulfur atom; Y represents an alkylene group having 1 to 7 carbon atoms which may be optionally substituted with a lower alkyl group, or Y represents an -A-O-B- group wherein A and B are the same or different and each independently represents an alkylene group having 1 to 3 carbon atoms which may be optionally substituted with a lower alkyl group is disclosed. Also disclosed are a pharmacologically acceptable salt of a compound of formula (I), an antihistaminic and antiallergic agent comprising a compound of formula (I), a pharmaceutical composition comprising a compound of formula (I), and a method for the treatment of an allergic disease by administering a compound of formula (I).

    摘要翻译： 由下述通式（I）表示的哌啶衍生物： worin R1和R2是相同或不同，并且各自unabhängigdarstellt氢原子，卤原子，低级烷基，或低级烷氧基; R 3表示氢原子或低级烷基; X darstellt到氧原子或硫原子; 具有可任选被低级烷基，或Y darstellt substituiertem到-AOB-组worin A和B是相同的或不同的，并且具有1至3的亚烷基基团的每个unabhängigdarstellt 1至7个碳原子的亚烷基基团Y的darstellt 这可能与低级烷基，任选地substituiertem碳原子是游离缺失盘。 所以游离缺失盘是式（I）中，在抗组胺和抗过敏剂，其包含式（I）的化合物的化合物，的药理学上可接受的盐的药物组合物包含式（I）的化合物，和用于的治疗的方法 通过施用式（I）的化合物的过敏性疾病。