发明授权
- 专利标题： COUMARIN DERIVATIVES FOR USE AS NUCLEOTIDE CROSSLINKING REAGENTS
- 专利标题（中）： 用作核苷交联试剂的香豆素衍生物
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申请号： EP90905935.4申请日： 1990-03-23
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公开(公告)号： EP0466773B1公开(公告)日： 1996-06-12
- 发明人: SABA, Don , GLASS, Richard, S. , YABUSAKI, Kenichi, K.
- 申请人： NAXCOR
- 申请人地址： 1035 San Pablo Avenue Suite 8 Albany, CA 94706 US
- 专利权人： NAXCOR
- 当前专利权人： NAXCOR
- 当前专利权人地址： 1035 San Pablo Avenue Suite 8 Albany, CA 94706 US
- 代理机构： Nicholls, Kathryn Margaret
- 优先权： US333632 19890405
- 国际公布： WO9012020 19901018
- 主分类号： C07H15/26
- IPC分类号： C07H15/26 ; C07H21/00
摘要：
A photoactivatable nucleoside analogue is disclosed, comprising a coumarin moiety linked through its phenyl ring to the 1-position of a ribose or deoxyribose sugar moiety. The resulting nucleoside analogue is typically used as a photocrosslinking group when inserted into a polynucleotide as a replacement for one or more of the complementary nucleoside bases present in a probe used in a hybridization assay.
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