发明公开
EP0475411A1 Novel carbocyclic adenosine analogs useful as immunosuppressants
失效
Neue als Immunsuppressivanützlichekarbozyklische Adenosinanaloge。
- 专利标题： Novel carbocyclic adenosine analogs useful as immunosuppressants
- 专利标题（中）： Neue als Immunsuppressivanützlichekarbozyklische Adenosinanaloge。
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申请号： EP91115485.4申请日： 1991-09-12
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公开(公告)号： EP0475411A1公开(公告)日： 1992-03-18
- 发明人: Borcherding, David R. , Edwards III, Carl K. , Esser, Ronald E. , Cole, Douglas L.
- 申请人： HOECHST MARION ROUSSEL, INC.
- 申请人地址： 9300 Ward Parkway Kansas City Missouri 64114-0480 US
- 专利权人： HOECHST MARION ROUSSEL, INC.
- 当前专利权人： HOECHST MARION ROUSSEL, INC.
- 当前专利权人地址： 9300 Ward Parkway Kansas City Missouri 64114-0480 US
- 代理机构： VOSSIUS & PARTNER
- 优先权： US582280 19900914; US748172 19910823
- 主分类号： C07D473/00
- IPC分类号： C07D473/00 ; C07D473/34 ; C07D487/04 ; C07D471/04 ; A61K31/52 ; A61K31/435 ; A61K31/44 ; A61K31/505
摘要：
This invention relates to novel carbocyclic adenosine compounds of the formula (1)
wherein
the hydroxy substituent on the cyclopentanyl ring is in the CIS configuration relative to the bicyclic substituent,
Y₃, Y₇, Y₈ and Y₉ are each independently nitrogen or a CH group,
Q is NH₂, halogen or hydrogen, and
Z is hydrogen, halogen, or NH₂;
or a pharmaceutically-acceptable salt thereof, and to their use as immunosuppressants.
wherein
the hydroxy substituent on the cyclopentanyl ring is in the CIS configuration relative to the bicyclic substituent,
Y₃, Y₇, Y₈ and Y₉ are each independently nitrogen or a CH group,
Q is NH₂, halogen or hydrogen, and
Z is hydrogen, halogen, or NH₂;
or a pharmaceutically-acceptable salt thereof, and to their use as immunosuppressants.
公开/授权文献
信息查询
IPC分类:
| C | 化学；冶金 |
| C07 | 有机化学 |
| C07D | 杂环化合物（高分子化合物入C08） |
| C07D473/00 | 含嘌呤环系的杂环化合物 |
