发明公开
EP0475413A2 Carbocyclic nucleoside analogs useful as immunosuppressants
失效
Carbocyklische Nukleosidanaloge als Immunsuppressoren。
- 专利标题： Carbocyclic nucleoside analogs useful as immunosuppressants
- 专利标题（中）： Carbocyklische Nukleosidanaloge als Immunsuppressoren。
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申请号： EP91115487.0申请日： 1991-09-12
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公开(公告)号： EP0475413A2公开(公告)日： 1992-03-18
- 发明人: Borcherding, David R. , Esser, Ronald E. , Edwards III, Carl K. , Cole, Douglas L.
- 申请人： HOECHST MARION ROUSSEL, INC.
- 申请人地址： 9300 Ward Parkway Kansas City Missouri 64114-0480 US
- 专利权人： HOECHST MARION ROUSSEL, INC.
- 当前专利权人： HOECHST MARION ROUSSEL, INC.
- 当前专利权人地址： 9300 Ward Parkway Kansas City Missouri 64114-0480 US
- 代理机构： VOSSIUS & PARTNER
- 优先权： US582265 19900914; US748173 19910823
- 主分类号： A61K31/70
- IPC分类号： A61K31/70 ; A61K31/52 ; A61K31/44 ; A61K31/505
摘要：
This invention relates to a method of effecting immunosuppression in a patient in need thereof comprising administering an effective amount of a compound of the formula (1)
wherein the hydroxy substituent on the cyclopentenyl ring is in the CIS configuration relative to the bicyclic substituent,
Y 3 , Y 7 , Y 8 and Y 9 are each independently nitrogen or a CH group,
Q is NH 2 , halogen or hydrogen, and
Z is hydrogen, halogen, or NH 2 ;
or a pharmaceutically-acceptable salt thereof.
wherein the hydroxy substituent on the cyclopentenyl ring is in the CIS configuration relative to the bicyclic substituent,
Y 3 , Y 7 , Y 8 and Y 9 are each independently nitrogen or a CH group,
Q is NH 2 , halogen or hydrogen, and
Z is hydrogen, halogen, or NH 2 ;
or a pharmaceutically-acceptable salt thereof.
公开/授权文献
- EP0475413B1 Carbocyclic nucleoside analogs useful as immunosuppressants 公开/授权日：1996-06-19
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