发明公开
- 专利标题： Pyrazoloquinoline derivatives
- 专利标题（中）： 吡唑并喹啉衍生物
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申请号： EP91115596.8申请日： 1991-09-13
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公开(公告)号： EP0476544A1公开(公告)日： 1992-03-25
- 发明人: Suzuki, Fumio , Nakasato, Yoshisuke , Ohmori, Kenji , Tamura, Tadafumi , Hosoe, Hisashi , Kubo, Kazuhiro , Yoshitake, Ikufumi
- 申请人： KYOWA HAKKO KOGYO CO., LTD.
- 申请人地址： 6-1, Ohtemachi 1-chome Chiyoda-ku, Tokyo-to JP
- 专利权人： KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人： KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人地址： 6-1, Ohtemachi 1-chome Chiyoda-ku, Tokyo-to JP
- 代理机构： VOSSIUS & PARTNER
- 优先权： JP245389/90 19900914
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K31/47
摘要：
A pyrazoloquinoline derivative having the formula (I):
wherein R¹, R², and R³ independently represent a hydrogen atom or a lower alkyl group; R⁴ represents a hydrogen atom, a lower alkyl group, a halogen-substituted lower alkyl group, or a lower alkoxycarbonyl group; the dotted line means that the pyrazole ring has two conjugated double bonds; and R⁴ is bonded to the nitrogen atom at the 1-position or 2-position, or pharmacologically acceptable salts thereof. These compounds exhibit excellent anti-inflammatory activity and hepatic insufficiency treating activity.
wherein R¹, R², and R³ independently represent a hydrogen atom or a lower alkyl group; R⁴ represents a hydrogen atom, a lower alkyl group, a halogen-substituted lower alkyl group, or a lower alkoxycarbonyl group; the dotted line means that the pyrazole ring has two conjugated double bonds; and R⁴ is bonded to the nitrogen atom at the 1-position or 2-position, or pharmacologically acceptable salts thereof. These compounds exhibit excellent anti-inflammatory activity and hepatic insufficiency treating activity.
公开/授权文献
- EP0476544B1 Pyrazoloquinoline derivatives 公开/授权日：1995-05-10
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