发明公开
- 专利标题： 1,2,3,6-Tetrahydropyridine derivatives
- 专利标题（中）： 1,2,3,6-四氢吡啶衍生物
-
申请号： EP91311257.9申请日： 1991-12-03
-
公开(公告)号： EP0490560A1公开(公告)日： 1992-06-17
- 发明人: Gizur, Tibor , Harsányi, Kálmán , Csehi, Attila , Demeter, Anikó , Trischler, Ferenc , Vajda, Eva , Szporny, László , Kiss, Béla , Kárpáti, Egon , Pálosi, Eva , Szombathelyi, Zsolt , Sarkadi, Adám , Gere, Anikó , Bodó, Mihály , Csomor, Katalin , Laszy, Judit Nagykovacsi , Szentirmai, Zsolt , Lapis, Erzsébet , Szabó, Sándor
- 申请人： RICHTER GEDEON VEGYESZETI GYAR R.T.
- 申请人地址： Gyömröi ut 19-21 H-1103 Budapest X HU
- 专利权人： RICHTER GEDEON VEGYESZETI GYAR R.T.
- 当前专利权人： RICHTER GEDEON VEGYESZETI GYAR R.T.
- 当前专利权人地址： Gyömröi ut 19-21 H-1103 Budapest X HU
- 代理机构： Harrison, David Christopher
- 优先权： HU825390 19901213
- 主分类号： C07D211/70
- IPC分类号： C07D211/70 ; A61K31/44
摘要：
The present invention relates to novel 1,2,3,6-tetrahydropyridine derivatives of the general formula (I)
- wherein
R stands for hydrogen or an alkyl group,
X stands for an unsubstituted phenyl or benzyl group or for a phenyl or benzyl group substituted with a halogen atom,
Y stands for hydrogen or halogen or a trifluoro-methyl group -
as well as enantiomers acid addition salts thereof.
The invention further extends to pharmaceutical compositions containing said compounds as active ingredient mainly for improving cerebral blood circulation and antihypoxic activity. The 1,2,3,6-tetrahydropyridine derivatives of the general formula (I) are prepared by treating an oxo derivative of the general formula (II)
wherein R, X and Y are as given above in an organic solvent by a reducing agent and reacting the obtained 1,2,3,6-tetrahydropyridine derivative of the general formula (I), wherein R, X and Y are as given above, with a mineral or organic acid and converting the same, if desired, to an acid addition salt.
- wherein
R stands for hydrogen or an alkyl group,
X stands for an unsubstituted phenyl or benzyl group or for a phenyl or benzyl group substituted with a halogen atom,
Y stands for hydrogen or halogen or a trifluoro-methyl group -
as well as enantiomers acid addition salts thereof.
The invention further extends to pharmaceutical compositions containing said compounds as active ingredient mainly for improving cerebral blood circulation and antihypoxic activity. The 1,2,3,6-tetrahydropyridine derivatives of the general formula (I) are prepared by treating an oxo derivative of the general formula (II)
wherein R, X and Y are as given above in an organic solvent by a reducing agent and reacting the obtained 1,2,3,6-tetrahydropyridine derivative of the general formula (I), wherein R, X and Y are as given above, with a mineral or organic acid and converting the same, if desired, to an acid addition salt.
公开/授权文献
- EP0490560B1 1,2,3,6-Tetrahydropyridine derivatives 公开/授权日：1996-03-20
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