发明授权
- 专利标题: A METHOD FOR SYNTHESIS OF PROSTAGLANDIN DERIVATIVES
- 专利标题(中): 合成方法的前列腺素
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申请号: EP91914853.6申请日: 1991-08-08
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公开(公告)号: EP0495069B1公开(公告)日: 1996-01-17
- 发明人: RESUL, Bahram
- 申请人: Pharmacia AB
- 申请人地址: S-171 97 Stockholm SE
- 专利权人: Pharmacia AB
- 当前专利权人: Pharmacia AB
- 当前专利权人地址: S-171 97 Stockholm SE
- 代理机构: Widén, Björn
- 优先权: SE9002596 19900808
- 国际公布: WO9202496 19920220
- 主分类号: C07C405/00
- IPC分类号: C07C405/00
摘要:
Method for preparing 13,14-dihydro-17-phenyl analogues of PGF2α or PGE2 comprising the step of hydrogenating the double bond in an intermediate compound (I) without deoxygenation of the allylic alcohol to give one of the intermediate compounds (II, III) wherein R is hydrogen or one or more halogen, hydroxyl, cyanide, alkyl (preferably 1-4 carbon atoms), hydroxyalkyl, trifluoromethyl or aromatic or heteroaromatic substituents on the aromatic ring R1 and R2 are each hydrogen, alkyl (preferably 1-4 carbon atoms), hydroxyl, halogen or hydroxyalkyl substituents, R3 is O-alkyl or N(alkyl), P is a protecting group.
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