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公开(公告)号：EP4431492A1
公开(公告)日：2024-09-18
申请号：EP22892634.1
申请日：2022-10-28
申请人： Warrantee Inc.
发明人： SHONO Yusuke , MAITI Bhimcharan
IPC分类号： C07C405/00 , A61K8/30 , A61K31/5575 , A61P17/14 , A61P27/02 , A61Q7/00 , C07C69/734 , C07D307/935
CPC分类号： Y02P20/55 , A61K8/30 , A61K31/5575 , A61P17/14 , A61P27/02 , A61Q7/00 , C07C69/734 , C07C405/00 , C07D307/935
摘要： At least one object of the present invention to provide a novel compound.
A compound represented by Chemical Formula (i):
wherein a bond indicated by parallel broken and solid lines represents a single bond or a double bond capable of taking a cis configuration or a trans configuration, R1 and R2 each represent hydrogen, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, an aryl group having 6 to 8 carbon atoms, or R4-C(=O)-, and R4 represents an alkyl group having 1 to 6 carbon atoms, R3 represents hydrogen, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, or an aryl group having 6 to 8 carbon atoms.-
公开(公告)号：EP3116854B1
公开(公告)日：2022-01-26
申请号：EP15715811.4
申请日：2015-03-11
发明人： VAJDA, Ervin , HORTOBÁGYI, Irén , LÁSZLÓFI, István , BUZDER-LANTOS, Péter , HAVASI, Gábor , TAKÁCS, László , KARDOS, Zsuzsanna
IPC分类号： C07C405/00 , B01D15/32
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公开(公告)号：EP1420794B1
公开(公告)日：2017-12-27
申请号：EP02767866.3
申请日：2002-08-29
申请人： Sucampo AG
发明人： UENO, Ryuji , CUPPOLETTI, John
IPC分类号： A61K31/557 , C07C405/00
CPC分类号： C07C405/00 , A61K31/557
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4.发明授权CRYSTAL FORM OF PROSTAGLANDIN ANALOGUE, AND PREPARATION METHOD AND USE THEREOF 有权前列腺素类似物的晶体形式及其制备方法和用途
公开(公告)号：EP2808318B1
公开(公告)日：2017-10-25
申请号：EP13736455.0
申请日：2013-01-10
发明人： TANG, Zhijun , LIU, Yubin , HE, Bingming , YANG, Jun , JI, Xiaoming
IPC分类号： C07C59/42 , C07C405/00 , A61K31/19 , A61K31/557 , A61P11/00
CPC分类号： C07C59/72 , C07B2200/13 , C07C59/66 , C07C2603/14
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5.发明公开NEW PROCESS FOR THE PREPARATION OF HIGH PURITY PROSTAGLANDINS 审中-公开邻近VERFAHREN ZUR HERSTELLUNG VON HOCHREINEN PROSTAGLANDINEN
公开(公告)号：EP3116854A1
公开(公告)日：2017-01-18
申请号：EP15715811.4
申请日：2015-03-11
发明人： VAJDA, Ervin , HORTOBÁGYI, Irén , LÁSZLOFI, István , BUZDER-LANTOS, Péter , HAVASI, Gábor , TÁKACS, László , KARDOS, Zsuzsanna
IPC分类号： C07C405/00
CPC分类号： C07C405/00 , B01D15/322 , C07C2601/08
摘要： The subject of the invention is a process for the preparation of high purity prostaglandin acid of the general formula II wherein the bonds marked with dotted lines represent single or double bonds wherein the double bonds may be cis- or trans oriented, Y represents 0 or CH 2, and R3 stands for a phenyl group which is optionally substituted with CF3, wherein the crude prostaglandin acid of the general formula II is purified by normal phase silicagel chromatography.
摘要翻译： 本发明的主题是制备通式II的高纯度前列腺素酸的方法，其中用虚线标记的键代表单键或双键，其中双键可以是顺式或反式取代的，Y代表0或CH 2，R3表示任选被CF 3取代的苯基，其中通式Ⅱ的粗制前列腺素酸通过正相硅胶色谱纯化。
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公开(公告)号：EP3002277A1
公开(公告)日：2016-04-06
申请号：EP15194684.5
申请日：2004-12-27
申请人： Nicox S.A.
IPC分类号： C07C405/00 , A61P27/06 , A61K31/5575
摘要： Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
摘要翻译： 描述了具有改善的药理活性和增强的耐受性的前列腺素硝基衍生物。 它们可用于治疗青光眼和高眼压症。
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公开(公告)号：EP1704141B1
公开(公告)日：2016-02-24
申请号：EP04804405.1
申请日：2004-12-27
申请人： Nicox S.A.
IPC分类号： C07C405/00 , A61P27/06 , A61K31/5575
CPC分类号： C07C405/0016
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公开(公告)号：EP2925720A1
公开(公告)日：2015-10-07
申请号：EP13811611.6
申请日：2013-11-26
IPC分类号： C07C405/00
CPC分类号： C07C67/42 , C07C405/00 , C07C2601/08
摘要： The subject of the invention is process the preparation of travoprost of formula (I) characterized by that the free acid of formula (II) is a.) activated with 2-chloro-1,3-dimethyl-imidazolinium chloride (DMC) and the resulting activated carboxylic acid intermediate is reacted with isopropyl alcohol, or b.) reacted with alkyl haloformate and the resulting mixed anhydride is reacted with isopropyl alcohol, or c.) activated with a straight or branched C1-8 dialkyl dicarbonate and reacted with isopropanol in the presence of water-free magnesium salt.
摘要翻译： 本发明的主题是制备式（I）的曲伏前列素，其特征在于式（II）的游离酸是用2-氯-1,3-二甲基 - 咪唑啉氯化物（DMC）活化的， 使活化的羧酸中间体与异丙醇反应，或b。）与卤代甲酸烷基酯反应，并将得到的混合酸酐与异丙醇反应，或c。用直链或支链C 1-8二烷基二碳酸酯活化并与异丙醇反应 存在无水镁盐。
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9.发明公开Processes for the preparation of isomer free prostaglandins 审中-公开前列腺素（Verfahren zur Herstellung Isomeren-freier Prostaglandine）
公开(公告)号：EP2837621A1
公开(公告)日：2015-02-18
申请号：EP14180866.7
申请日：2014-08-13
发明人： Wei, Shih-Yi , Yeh, Yu-Chih , Hsu, Min-Kuan , Kao, Li-Ta
IPC分类号： C07C405/00 , C07D313/00
摘要： Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6- trans isomer:
wherein
R 2 , R 3 and R 4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.摘要翻译： 制备基本上不含5,6-反式异构体的式I-2化合物的新方法：其中R 2，R 3和R 4如说明书中所定义。 还提供了用于制备不含异构体的前列腺素及其衍生物的新型中间体。
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10.发明公开A CRYSTALLINE FORM OF BIMATOPROST, PREPARATION METHOD AND USE THEREOF 审中-公开KRISTALLINE FORM VON BIMATOPROST SOWIE HERSTELLUNGSVERFAHRENDAFÜRUND VERWENDUNG DAVON
公开(公告)号：EP2497766A4
公开(公告)日：2014-10-15
申请号：EP10826001
申请日：2010-07-30
发明人： HE BINGMING , TANG ZHIJUN , ZHUO ZHONGHAO , ZHENG YUNMAN , GAO XIAOLIANG , JI XIAOMING
IPC分类号： C07C405/00 , A61K31/16 , A61P27/06
CPC分类号： C07C405/00 , C07B2200/13 , C07C2601/08
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