发明公开
EP0496973A3 Somatotropins with alterations in the alpha-helix 1 region, and combinations with other mutations
失效
在ALPHA-HELIX 1地区具有改变的SOMATOTROPINS，以及与其他突变体的组合
- 专利标题： Somatotropins with alterations in the alpha-helix 1 region, and combinations with other mutations
- 专利标题（中）： 在ALPHA-HELIX 1地区具有改变的SOMATOTROPINS，以及与其他突变体的组合
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申请号： EP91120396.6申请日： 1991-11-28
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公开(公告)号： EP0496973A3公开(公告)日： 1993-02-24
- 发明人: Fischer, Meir , Lebens, Michael Richard , Chaleff, Deborah Tardy
- 申请人： BIO-TECHNOLOGY GENERAL CORPORATION , AMERICAN CYANAMID COMPANY
- 申请人地址： 1250 Broadway New York NY 10001 US
- 专利权人： BIO-TECHNOLOGY GENERAL CORPORATION,AMERICAN CYANAMID COMPANY
- 当前专利权人： BIO-TECHNOLOGY GENERAL CORPORATION,AMERICAN CYANAMID COMPANY
- 当前专利权人地址： 1250 Broadway New York NY 10001 US
- 代理机构： Wächtershäuser, Günter, Prof. Dr.
- 优先权： US621656 19901130
- 主分类号： C12N15/18
- IPC分类号： C12N15/18 ; C07K13/00 ; C07K3/08
摘要：
The present invention relates to somatotropin analogues with amino acid changes in the alpha-helix 1 regions of said somatotropins, alone or in combination with mutations in the alpha-helix 3 and/or alpha-helix 2 regions, plus combinations with other changes to the native amino acid sequence of somatotropins. The resulting analogues are stable for formulation in sustained release formulations, while maintaining biological activity. Further, methods for conducting site-directed mutagenesis on DNA encoding proteins and/or polypeptide also are provided.
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