发明公开
- 专利标题： Quinone derivatives
- 专利标题（中）： 希农衍。
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申请号： EP92103555.6申请日： 1992-03-02
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公开(公告)号： EP0503426A1公开(公告)日： 1992-09-16
- 发明人: Okamoto, Yasushi , Tagami, Katsuya , Hibi, Shigeki , Numata, Hirotoshi , Kawahara, Tetsuya , Kobayashi, Naoki , Shinoda, Masanobu , Harada, Koukichi , Miyamoto, Kaname , Abe, Koichi
- 申请人： Eisai Co., Ltd.
- 申请人地址： 6-10, Koishikawa 4-chome Bunkyo-ku Tokyo JP
- 专利权人： Eisai Co., Ltd.
- 当前专利权人： Eisai Co., Ltd.
- 当前专利权人地址： 6-10, Koishikawa 4-chome Bunkyo-ku Tokyo JP
- 代理机构： Kirschner, Klaus Dieter, Dipl.-Phys.
- 优先权： JP44709/91 19910311; JP178161/91 19910718
- 主分类号： C07D213/55
- IPC分类号： C07D213/55 ; C07D213/56 ; A61K31/44
摘要：
The object of the present invention is to provide a quinone derivative exhibiting an excellent activity as a drug.
The present invention provides a quinone derivative represented by the general formula (I) or a pharmacologically acceptable salt thereof:
wherein A stands for a group represented by the formula:
(wherein R³, R⁴ and R⁵ is the same or different from each other and each stand for a hydrogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, an alkoxyalkyl group, an alkoxyalkoxy group, a cycloalkylalkoxy group, a thiol group or a thioalkyl group, with the proviso that a case wherein R³ and R⁴ are each a lower alkoxy group simultaneously is excepted) or a group represented by the formula:
(wherein R³, R⁴ and R⁵ is the same or different from each other and each stand for a hydrogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, an alkoxyalkyl group, an alkoxyalkoxy group, a cycloalkylalkoxy group, a thiol group or a thioalkyl group, with the proviso that a case wherein R³ and R⁴ are each a lower alkoxy group simultaneously is excepted; X and Y is the same or different from each other and each stand for a hydroxyl group or a protected hydroxyl group);
R¹ stands for a heteroarylalkyl group; and
B stands for a carboxyl group or a protected carboxyl group.
The present invention provides a quinone derivative represented by the general formula (I) or a pharmacologically acceptable salt thereof:
wherein A stands for a group represented by the formula:
(wherein R³, R⁴ and R⁵ is the same or different from each other and each stand for a hydrogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, an alkoxyalkyl group, an alkoxyalkoxy group, a cycloalkylalkoxy group, a thiol group or a thioalkyl group, with the proviso that a case wherein R³ and R⁴ are each a lower alkoxy group simultaneously is excepted) or a group represented by the formula:
(wherein R³, R⁴ and R⁵ is the same or different from each other and each stand for a hydrogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, an alkoxyalkyl group, an alkoxyalkoxy group, a cycloalkylalkoxy group, a thiol group or a thioalkyl group, with the proviso that a case wherein R³ and R⁴ are each a lower alkoxy group simultaneously is excepted; X and Y is the same or different from each other and each stand for a hydroxyl group or a protected hydroxyl group);
R¹ stands for a heteroarylalkyl group; and
B stands for a carboxyl group or a protected carboxyl group.
公开/授权文献
- EP0503426B1 Quinone derivatives 公开/授权日：1996-12-27
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