发明公开
EP0513398A4 INTERMEDIATE FOR SYNTHESIS OF CARBAPENEM AND PRODUCTION OF SAID INTERMEDIATE
失效
中间体用于合成碳水化合物和生产中间体
- 专利标题： INTERMEDIATE FOR SYNTHESIS OF CARBAPENEM AND PRODUCTION OF SAID INTERMEDIATE
- 专利标题（中）： 中间体用于合成碳水化合物和生产中间体
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申请号： EP92902498申请日： 1991-11-26
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公开(公告)号： EP0513398A4公开(公告)日： 1993-03-24
- 发明人: SAKURAI, KUNIYA, AJINOMOTO CO.,INC. CHUOKENKYUSYO , IZAWA, KUNISUKE, AJINOMOTO CO.,INC. CHUOKENKYUSYO , IZAWA, HIROYUKI, AJINOMOTO CO.,INC. CHUOKENKYUSYO , INEYAMA, TAKASHI, AJINOMOTO CO.,INC.CHUOKENKYUSYO , OHTA, TOMIHISA, 3-1-202, MIKAMINE 1-CHOME , NOZOE, SHIGEO, 10-4, YAGIYAMAHONCHO 1-CHOME
- 申请人： AJINOMOTO CO., INC.
- 申请人地址： 15-1, KYOBASHI 1-CHOME, CHUO-KU; TOKYO 104
- 专利权人： AJINOMOTO CO., INC.
- 当前专利权人： AJINOMOTO CO., INC.
- 当前专利权人地址： 15-1, KYOBASHI 1-CHOME, CHUO-KU; TOKYO 104
- 优先权： JP32476190 1990-11-27; JP32768190 1990-11-28
- 主分类号： C07D207/16
- IPC分类号： C07D207/16 ; C07D401/06 ; C07D477/02 ; C07D477/04 ; C07D477/14 ; C07D477/20 ; C07D477/00
摘要：
A carbapenem derivative having an R-configuration at the 5-position, represented by general formula (I), and optically active pyrrolidine derivatives represented by general formulae (XI) and (XII), all of these compounds serving as the intermediate for the synthesis of carbapenems as β-lactam antibiotics. In formula (I) R1 represents hydrogen or an organic group; and R2 represents hydrogen or a carboxyl protective group. In formulae (XI) and (XII) R1 represents benzyl; R2 represents alkyl; R3 represents alkyl, benzyl or allyl; R4 represents hydrogen, alkyl, vinyl, phenyl, benzyl or a heterocyclic group containing 1 to 4 nitrogen or/and oxygen atoms; and R5 represents hydrogen or methyl.
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