公开(公告)号：EP0513398A4

公开(公告)日：1993-03-24

申请号：EP92902498

申请日：1991-11-26

申请人： AJINOMOTO CO., INC.

发明人： SAKURAI, KUNIYA, AJINOMOTO CO.,INC. CHUOKENKYUSYO ,  IZAWA, KUNISUKE, AJINOMOTO CO.,INC. CHUOKENKYUSYO ,  IZAWA, HIROYUKI, AJINOMOTO CO.,INC. CHUOKENKYUSYO ,  INEYAMA, TAKASHI, AJINOMOTO CO.,INC.CHUOKENKYUSYO ,  OHTA, TOMIHISA, 3-1-202, MIKAMINE 1-CHOME ,  NOZOE, SHIGEO, 10-4, YAGIYAMAHONCHO 1-CHOME

IPC分类号： C07D207/16 ,  C07D401/06 ,  C07D477/02 ,  C07D477/04 ,  C07D477/14 ,  C07D477/20 ,  C07D477/00

CPC分类号： C07D477/20 ,  C07D207/16 ,  C07D401/06 ,  C07D477/02 ,  C07D477/04 ,  C07D477/14 ,  Y02P20/55

摘要： A carbapenem derivative having an R-configuration at the 5-position, represented by general formula (I), and optically active pyrrolidine derivatives represented by general formulae (XI) and (XII), all of these compounds serving as the intermediate for the synthesis of carbapenems as β-lactam antibiotics. In formula (I) R1 represents hydrogen or an organic group; and R2 represents hydrogen or a carboxyl protective group. In formulae (XI) and (XII) R1 represents benzyl; R2 represents alkyl; R3 represents alkyl, benzyl or allyl; R4 represents hydrogen, alkyl, vinyl, phenyl, benzyl or a heterocyclic group containing 1 to 4 nitrogen or/and oxygen atoms; and R5 represents hydrogen or methyl.