发明公开
EP0514359A3 Alkanoyl L-carnitine amides with aminoacids and pharmaceutical compositions containing same, for promoting regeneration of the nervous tissue, inhibiting neuronal degeneration, enhancing the processes of learning and memory, and for the treatment of coma
失效
碱性L-卡那胺与含有氨基酸的药物和药物组合物一起用于促进神经组织的再生，抑制神经衰弱，增强学习和记忆的过程以及治疗COMA
- 专利标题： Alkanoyl L-carnitine amides with aminoacids and pharmaceutical compositions containing same, for promoting regeneration of the nervous tissue, inhibiting neuronal degeneration, enhancing the processes of learning and memory, and for the treatment of coma
- 专利标题（中）： 碱性L-卡那胺与含有氨基酸的药物和药物组合物一起用于促进神经组织的再生，抑制神经衰弱，增强学习和记忆的过程以及治疗COMA
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申请号： EP92830224.9申请日： 1992-05-14
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公开(公告)号： EP0514359A3公开(公告)日： 1993-03-10
- 发明人: Taglialatela, Giulio , Fanto', Nicola , Santaniello, Mosè , Cavazza, Claudio
- 申请人： Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
- 申请人地址： Viale Shakespeare, 47 I-00144 Roma IT
- 专利权人： Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
- 当前专利权人： Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
- 当前专利权人地址： Viale Shakespeare, 47 I-00144 Roma IT
- 代理机构： Fassi, Aldo
- 优先权： ITRM910333 19910516
- 主分类号： C07C237/12
- IPC分类号： C07C237/12 ; A61K31/22
摘要：
Amides of alkanoyl L-carnitines of general formula (1).
wherein R is a straight or branched alkanoyl group having from 2 to 8 carbon atoms selected from acetyl, propionyl, butyryl, isobutyryl, valeryl, isovaleryl, hexanoyl, 1-methylbutyryl, t-butylacetyl, 2-ethylbutyryl, 3-methylvaleryl, 4-methylvaleryl, 2-ethylhexanoyl and 2-propylpentanoyl;
R' is the monovalent residue of a naturally occurring aminoacid selected from:
and X - is the anion of a pharmacologically acceptable acid are active in regenerating the nervous tissue, inhibiting neuronal degeneration, enhancing the processes of learning and memory and for the treatment of coma. Orally or parenterally administrable compositions in unit dosage form comprise between about 50 and about 500 mg of an amide of formula (1).
wherein R is a straight or branched alkanoyl group having from 2 to 8 carbon atoms selected from acetyl, propionyl, butyryl, isobutyryl, valeryl, isovaleryl, hexanoyl, 1-methylbutyryl, t-butylacetyl, 2-ethylbutyryl, 3-methylvaleryl, 4-methylvaleryl, 2-ethylhexanoyl and 2-propylpentanoyl;
R' is the monovalent residue of a naturally occurring aminoacid selected from:
and X - is the anion of a pharmacologically acceptable acid are active in regenerating the nervous tissue, inhibiting neuronal degeneration, enhancing the processes of learning and memory and for the treatment of coma. Orally or parenterally administrable compositions in unit dosage form comprise between about 50 and about 500 mg of an amide of formula (1).
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