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    Use of esters of acyl carnitines with long-chain aliphatic alcohols in the preparation of pharmaceutical compositions having antimycotic activity
    2.
    发明公开
    Use of esters of acyl carnitines with long-chain aliphatic alcohols in the preparation of pharmaceutical compositions having antimycotic activity 失效
    酰基肉碱的酯与长链脂族醇，以及含有它们具有抗真菌活性的药物组合物。

    公开(公告)号：EP0552138A2

    公开(公告)日：1993-07-21

    申请号：EP93830010.0

    申请日：1993-01-15

    申请人： Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

    发明人： Santaniello, Mosè ,  Tinti, Maria Ornella ,  Misiti, Domenico ,  Foresta, Piero

    IPC分类号： C07C229/22 ,  A61K31/195 ,  A61K31/22

    CPC分类号： C07C229/22

    摘要： Esters of acyl L-carnitines of general formula (I)
    wherein

    R is a straight or branched acyl group having 2 to 16 carbon atoms, in particular isobutyryl and isovaleryl ;
    n is an integer comprised between 7 and 15, particularly 10 ; and,
    X- is the anion of a pharmacologically acceptable acid are endowed with potent antimycotic activity particularly against yeast like fungi, such as Candida albicans, the aetiologic agent of candidiasis and against filamentous fungi, such as Aspergillus fumigatus, the aetiologic agent of aspergillosis.
    Orally or parenterally administrable or topically applicable pharmaceutical compositions comprise an ester of formula (I) as active ingredient.

    摘要翻译： 通式（I） worin R是具有2至16个碳原子，特别是异丁和异戊酰基的直链或支链酰基的N-酰基L-肉碱的酯; n为7和15，特别是10之间包含的整数; 并且，X是被赋予了特别是对样真菌,:如白色念珠菌，念珠菌aetiologic剂和抗丝状真菌，：例如烟曲霉病，曲霉病的aetiologic剂酵母有效的抗真菌活性的药理学上可接受酸的阴离子。 口服或肠胃外给药或局部应用药物组合物包含式（I）作为活性的酯的成分。