发明公开
EP0525420A1 Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors
失效
假肽和二肽，其在C末端为巯基蛋白酶抑制剂的特征在于取代的Methylketoneinheit。
- 专利标题： Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors
- 专利标题（中）： 假肽和二肽，其在C末端为巯基蛋白酶抑制剂的特征在于取代的Methylketoneinheit。
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申请号： EP92111129.0申请日： 1992-07-01
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公开(公告)号： EP0525420A1公开(公告)日： 1993-02-03
- 发明人: Ando, Ryoichi , Ando, Naoko , Masuda, Hirokazu , Morinaka, Yasuhiro , Takahashi, Chizuko , Tamao, Yoshikuni , Tobe, Akihiro
- 申请人： Mitsubishi Chemical Corporation
- 申请人地址： 5-2, Marunouchi 2-chome Chiyoda-ku Tokyo JP
- 专利权人： Mitsubishi Chemical Corporation
- 当前专利权人： Mitsubishi Chemical Corporation
- 当前专利权人地址： 5-2, Marunouchi 2-chome Chiyoda-ku Tokyo JP
- 代理机构： Hansen, Bernd, Dr. Dipl.-Chem.
- 优先权： JP160674/91 19910701; JP277905/91 19911024; JP343668/91 19911225
- 主分类号： C07D307/56
- IPC分类号： C07D307/56 ; C07D307/84 ; C07D307/85 ; C07D307/68 ; C07D307/38 ; C07D307/42 ; C07D307/52 ; C07D213/32 ; C07D235/06 ; C07D261/08 ; C07D263/20 ; C07D277/26 ; C07D295/125 ; C07D405/12 ; C07D407/12 ; C07D409/12 ; C07C271/54 ; C07C317/28 ; C07C323/41 ; C07K5/06 ; A61K31/16 ; A61K31/325 ; A61K31/34 ; A61K31/35 ; A61K31/36 ; A61K31/38 ; A61K31/44
摘要：
A novel ketone derivative (I) which possesses a potent inhibitory activity against thiol protease such as papain, cathepsin B, cathepsin H, cathepsin L, calpain or the like with excellent properties regarding oral absorbance, tissue transference and cell membrane permeability, and are clinically useful in the treatment of various diseases such as muscular dystrophy, amyotrophy. Also provided are a process for producing the compound (I) and a pharmaceutical composition containing the same.
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