发明公开
EP0528209A1 Process for preparing intermediates for vitamin D derivatives and novel compounds obtained thereby
失效
一种制备用于维生素D衍生物和新颖的化合物的中间体的过程。
- 专利标题： Process for preparing intermediates for vitamin D derivatives and novel compounds obtained thereby
- 专利标题（中）： 一种制备用于维生素D衍生物和新颖的化合物的中间体的过程。
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申请号： EP92112775.9申请日： 1992-07-27
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公开(公告)号： EP0528209A1公开(公告)日： 1993-02-24
- 发明人: Manchand, Percy Sarwood , Yiannikouros, George Petros
- 申请人： F. HOFFMANN-LA ROCHE AG
- 申请人地址： Postfach 3255 CH-4002 Basel CH
- 专利权人： F. HOFFMANN-LA ROCHE AG
- 当前专利权人： F. HOFFMANN-LA ROCHE AG
- 当前专利权人地址： Postfach 3255 CH-4002 Basel CH
- 代理机构： Grossner, Lutz, Dr.
- 优先权： US742796 19910809
- 主分类号： C07F7/18
- IPC分类号： C07F7/18 ; C07C401/00
摘要：
Compounds of the formula
wherein A is a 23,24-bisnorsteroid or a 23,24-bisnor-9,10-secosteroid radical, wherein the free valence bond is in the 22-position and wherein any hydroxy groups present are protected; R₁ is hydrogen, carboxy,
lower alkoxycarbonyl, lower alkylcarbonyl or unsubstituted or substituted lower alkyl; and R₂ is hydroxyl, lower alkoxy, or unusbstituted or substituted lower alkyl,
can be prepared from compounds of formula AX wherein X is halogen, and compounds of formula
The compounds of formula IV can be converted into calcitriol and related compounds.
wherein A is a 23,24-bisnorsteroid or a 23,24-bisnor-9,10-secosteroid radical, wherein the free valence bond is in the 22-position and wherein any hydroxy groups present are protected; R₁ is hydrogen, carboxy,
lower alkoxycarbonyl, lower alkylcarbonyl or unsubstituted or substituted lower alkyl; and R₂ is hydroxyl, lower alkoxy, or unusbstituted or substituted lower alkyl,
can be prepared from compounds of formula AX wherein X is halogen, and compounds of formula
The compounds of formula IV can be converted into calcitriol and related compounds.
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