发明公开
EP0541168A1 HIV protease inhibitors useful for the treatment of aids
失效
HIV-Protease-Inhibitoren verwendbar in der AIDS-Behandlung。
- 专利标题： HIV protease inhibitors useful for the treatment of aids
- 专利标题（中）： HIV-Protease-Inhibitoren verwendbar in der AIDS-Behandlung。
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申请号： EP92203357.6申请日： 1992-11-02
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公开(公告)号： EP0541168A1公开(公告)日： 1993-05-12
- 发明人: Vacca, Joseph P. , Holloway, M. Katharine , Dorsey, Bruce D. , Hungate, Randall W. , Guare, James P.
- 申请人： MERCK & CO. INC.
- 申请人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 专利权人： MERCK & CO. INC.
- 当前专利权人： MERCK & CO. INC.
- 当前专利权人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 代理机构： Barrett-Major, Julie Diane
- 优先权： US789508 19911108; US883825 19920515
- 主分类号： C07D217/26
- IPC分类号： C07D217/26 ; C07D241/04 ; C07D409/12 ; A61K31/47 ; A61K31/495
摘要：
Compounds of formula
where R 1 and R 2 are independently hydrogen or optionally-substituted C 1-4 alkyl or aryl, or R 1 and R 2 are joined together to form a monocyclic or bicyclic ring system, are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
where R 1 and R 2 are independently hydrogen or optionally-substituted C 1-4 alkyl or aryl, or R 1 and R 2 are joined together to form a monocyclic or bicyclic ring system, are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
公开/授权文献
- EP0541168B1 HIV protease inhibitors useful for the treatment of aids 公开/授权日：1998-03-11
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