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公开(公告)号：EP0541168B1
公开(公告)日：1998-03-11
申请号：EP92203357.6
申请日：1992-11-02
申请人： Merck & Co., Inc.
发明人： Vacca, Joseph P. , Holloway, M. Katharine , Dorsey, Bruce D. , Hungate, Randall W. , Guare, James P.
IPC分类号： C07D217/26 , C07D241/04 , C07D409/12 , A61K31/47 , A61K31/495
CPC分类号： C07D401/06 , C07D207/16 , C07D211/60 , C07D217/26 , C07D241/04 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D417/12
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2.发明公开HIV protease inhibitors in pharmaceutical combinant for the treatment of AIDS 失效艾滋病毒蛋白酶血液在pharmazeutischen Zusammensetzungen zur Behandlung von艾滋病。
公开(公告)号：EP0617968A1
公开(公告)日：1994-10-05
申请号：EP94302260.8
申请日：1994-03-29
申请人： MERCK & CO. INC.
发明人： Vacca, Joseph P. , Holloway, M. Katharine , Guare, James P. , Hungate, Randall W. , Dorsey, Bruce D.
CPC分类号： A61K31/70 , A61K45/06 , A61K2300/00
摘要： Compounds of formula
where R₁ and R₂ are independently hydrogen or optionally-substituted C₁₋₄alkyl or aryl, or R₁ and R₂ are joined together to form a monocyclic or bicyclic ring system, are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.摘要翻译： 其中R 1和R 2独立地为氢或任选取代的C 1-4烷基或芳基，或R 1和R 2连接在一起形成单环或双环环系的式
化合物是HIV蛋白酶抑制剂。 这些化合物可用于预防或治疗艾滋病毒和艾滋病感染，作为化合物，药学上可接受的盐，药物组合物成分，无论是否与其他抗病毒剂，免疫调节剂，抗生素或疫苗结合使用。 还描述了治疗AIDS的方法和预防或治疗HIV感染的方法。 -
3.发明授权HIV protease inhibitors in pharmaceutical combinations for the treatment of AIDS 失效在药物组合物的HIV蛋白酶抑制剂为爱滋病的治疗
公开(公告)号：EP0617968B1
公开(公告)日：2003-01-08
申请号：EP94302260.8
申请日：1994-03-29
申请人： Merck & Co., Inc.
发明人： Vacca, Joseph P. , Holloway, M. Katharine , Guare, James P. , Hungate, Randall W. , Dorsey, Bruce D.
CPC分类号： A61K31/70 , A61K45/06 , A61K2300/00
摘要： Compounds of formula where R1 and R2 are independently hydrogen or optionally-substituted C1-4alkyl or aryl, or R1 and R2 are joined together to form a monocyclic or bicyclic ring system, are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
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4.发明公开HIV protease inhibitors useful for the treatment of aids 失效HIV-Protease-Inhibitoren verwendbar in der AIDS-Behandlung。
公开(公告)号：EP0541168A1
公开(公告)日：1993-05-12
申请号：EP92203357.6
申请日：1992-11-02
申请人： MERCK & CO. INC.
发明人： Vacca, Joseph P. , Holloway, M. Katharine , Dorsey, Bruce D. , Hungate, Randall W. , Guare, James P.
IPC分类号： C07D217/26 , C07D241/04 , C07D409/12 , A61K31/47 , A61K31/495
CPC分类号： C07D401/06 , C07D207/16 , C07D211/60 , C07D217/26 , C07D241/04 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D417/12
摘要： Compounds of formula
where R 1 and R 2 are independently hydrogen or optionally-substituted C 1-4 alkyl or aryl, or R 1 and R 2 are joined together to form a monocyclic or bicyclic ring system, are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.摘要翻译： 式
的化合物，其中R 1和R 2独立地是氢或任选取代的C 5 -C 16烷基或芳基，或R 1和R 2连接在一起形成 单环或双环系统，是HIV蛋白酶抑制剂。 这些化合物可用于预防或治疗艾滋病毒和艾滋病感染，作为化合物，药学上可接受的盐，药物组合物成分，无论是否与其他抗病毒剂，免疫调节剂，抗生素或疫苗结合使用。 还描述了治疗AIDS的方法和预防或治疗HIV感染的方法。
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