发明公开
EP0556630A2 Process for the synthesis of exomethylenecephams
失效
Verfahren zur Herstellung von Exomethylencephams。
- 专利标题： Process for the synthesis of exomethylenecephams
- 专利标题（中）： Verfahren zur Herstellung von Exomethylencephams。
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申请号： EP93101588.7申请日： 1993-02-02
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公开(公告)号： EP0556630A2公开(公告)日： 1993-08-25
- 发明人: Cabri, Walter , Candiani, Ilaria , Bedeschi, Angelo
- 申请人： PHARMACIA S.p.A.
- 申请人地址： Via Robert Koch, 1.2 I-20152 Milano IT
- 专利权人： PHARMACIA S.p.A.
- 当前专利权人： PHARMACIA S.p.A.
- 当前专利权人地址： Via Robert Koch, 1.2 I-20152 Milano IT
- 代理机构： Ferrario, Vittorino
- 优先权： GB9203327 19920217
- 主分类号： C07D501/18
- IPC分类号： C07D501/18 ; C07D501/20 ; C07D501/04 ; C07D501/00 ; C07D501/59
摘要：
The present invention relates to a process for the preparation of exomethylene cephams, which are useful intermediates in the production of many useful β-lactam antibiotics.
More particularly there is provided a process for preparing a compound of formula I
wherein n is O or 1, R₁ is hydrogen atom or an organic residue and R₂ is a carboxy protecting group, which process comprises reacting a compound of the formula II
wherein X is halogen atom or acetoxy group and R₁ n and R₂ are as defined above with a lanthanide complex.
More particularly there is provided a process for preparing a compound of formula I
wherein n is O or 1, R₁ is hydrogen atom or an organic residue and R₂ is a carboxy protecting group, which process comprises reacting a compound of the formula II
wherein X is halogen atom or acetoxy group and R₁ n and R₂ are as defined above with a lanthanide complex.
公开/授权文献
- EP0556630A3 Process for the synthesis of exomethylenecephams 公开/授权日：1993-11-24
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